Volume 1 (2015) - Issue 11, November
Poor solubility remains one of the more challenging and critical task in drug discovery and development and it is also the main cause of low bioavailability and poor therapeutic efficacy of the drug. Many solubility enhancement techniques are available in literature like cyclodextrin inclusion complexes, salt formation, solid dispersion, drug delivery carrier approach and prodrug approach are usef...
A Simple, accurate and precise high performance thin layer chromatography method for the simultaneous estimation of ibuprofen and carisoprodol in marketed formulation was developed. The determination was carried on silica gel 60 GF254 HPTLC plates using a mobile phase n-butanol : glacial acetic acid: Acetone (5:2:3 v/v/v). The absorbance of the spots was measured by densitometry at 254 nm. The Ret...