Volume 3 (2017) - Issue 5, May
STABILITY INDICATING HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FOR CARVEDILOL IN BULK DRUG AND IN SOLID LIPID NANOPARTICLES
A stability indicating high-performance thin-layer chromatographic method (HPTLC) was developed and validated as per the International Conference on Harmonization (ICH) guidelines for determination of carvedilol (CRL) both in bulk drug and solid lipid nanoparticles (SLNs). The solvent system comprised of toluene–chloroform-methanol-acetic acid (2.0:2.0:1.0:0.04, v/v/v), gave compact spot of CRL ...
FORMULATION AND PERFORMANCE EVALUATION OF ESCITALOPRAM LOADED BIO-NANO SUSPENSION USING A NOVEL BIO-RETARDENT FROM PIPER NIGRUM
Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore novelistic route for targeting to brain through ear by formulating nanosuspension using escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardio-vascular diseases. The delivery has overcome...