FORMULATION AND PERFORMANCE EVALUATION OF ESCITALOPRAM LOADED BIO-NANO SUSPENSION USING A NOVEL BIO-RETARDENT FROM PIPER NIGRUMAbstract
Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore novelistic route for targeting to brain through ear by formulating nanosuspension using escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardio-vascular diseases. The delivery has overcome the dose dumping problem in case of oral system. In this research work significant effort was made to explore novelistic platform for ear to brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 hours. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having r2 value of 0.9905 tT80: 22 hrs and best fit model was found to be higuchi matrix, and mechanism of transport was anomalous transport which was calculated by bits software. According to the in-vitro results obtained it can be concluded that significant amount of drug reaches to the brain via external acoustic meatus. The demand for curbing depression and other mental health conditions is on the rise globally. Nano suspensions are distinctive and commercially feasible approach to solve the problems of hydrophobic drug such as poor solubility and poor bioavailability.
D. Raina and N.V. S. Madhav*
NRI Vidyadayani Institute of Science, Management and Technology, Bhopal, Madhya Pradesh, India.
07 March, 2017
11 May, 2017
16 May, 2017
31 May, 2017