WAFER TECHNOLOGY AS A NOVEL DRUG DELIVERY SYSTEMAbstract
The buccal cavity is considering as a door for the digestive system. It is composed of the teeth, tongue and palate. When the food enters to the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine and anal opening. When the drug taken by buccal delivery system, it decreases the time needed for the drug to give its action, progress the therapeutic action of the drug and give a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, presystemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and give response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and systemically.