Several liquid crystalline phases are bicontinuous cubic, reversed hexagonally, or reversed cubic phase, and several nanostructure liquid phases. Of the many liquid crystalline phases, bicontinuous cubic phases possess a special status. Dispersed particles of bicontinuous cubic liquid crystalline phase (cubosomes) are self-assembled nanostructured particles that can be formed in aqueous lipid and ...
IDENTIFICATION OF PHYTOCONSTITUENTS PRESENT IN EPIPREMNUM AUREUM (LINDEN AND ANDRE) G. S. BUNTING BY GC-MS
Introduction: Chromatographic purification methanolic extract of Epipremnum aureum (Linden and Andre) G. S. Bunting by Gas Chromatography-Mass Spectrometry (GC-MS) was done to analyze the phytochemical constituents for further pharmacological uses. Methods: Ten grams of fresh leaves of plant sample was subjected to solvent extraction with methanol and analyzed by GC-MS on a GCMS-2010 Shimadzu inst...
Ficus religiosa Linn. is a large evergreen tree found throughout India, wild as well as cultivated, it is widely branched tree with leathery, heart-shaped, long tipped leaves. It is a sacred plant in India. It is one of the most versatile plants having a wide variety of medicinal activities, therefore, used in the treatment of several types of diseases, e.g., diarrhea, diabetes, urinary disorders,...
Poor solubility remains one of the more challenging and critical tasks in drug discovery and development, and it is also the main cause of low bioavailability and poor therapeutic efficacy of the drug. Many solubility enhancement techniques are available in literature like cyclodextrin inclusion complexes, salt formation, solid dispersion, drug delivery carrier approach and prodrug approach are us...
Clitoria ternatea, commonly known as Butterfly pea, is a medicinal plant belonging to the family Fabaceae. The plant is reported to be used in lithiasis, insect bites, skin diseases, asthma, burning sensation, ascites, inflammation, leucoderma, leprosy, hemicrania, amentia, and pulmonary tuberculosis. It is commonly called “Shankpushpi” in the Sanskrit language where it is reported to be a goo...
Mikania cordata which belongs to the family Asteraceae is a medicinal plant that has been widely distributed through Southeast Asia and Eastern Africa. It possesses various therapeutic properties which include – anti-inflammatory, anti-ulcer, bronco-dilating, analgesic, antibiotic, anti-diarrheal, hepatoprotective, epidermal or skin protective, coagulative, anticarcinogenic, CNS depressant, anti...
Transdermal drug delivery system was first introduced more than 30 years ago. The technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. Skin acts as a major target as well as a principal barrier for topical/transdermal drug deliver...
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDSORAL REHYDRATION SALTIN AYSAITA TOWN, AFAR REGIONAL STATE, NORTHEASTERN ETHIOPIA
Introduction: Oral rehydration therapy is a life-saving intervention to save the lives of children. However, millions of children die every year due to failure to replace body fluid effectively. Therefore, this study was aimed to assess knowledge, attitude, and practice (KAP) of caretakers towards ORS on the management of diarrhea among under-five children in Aysaita town, Afar Regional State, Eth...
Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. The present research work was an attempt to formulate and evaluate paliperidone delayed-release tablets. A combination of hydroxypropyl methylcellulose (HPMC K100M) and polyvinyl acetate phthalate, cellulose acetate phthalate were used as polymers. The tablets were prepared by direct compression method. 12 formul...
SUSTAIN RELEASE FORMULATION AND EVALUATION OF CIPROFLOXACIN SUSTAIN RELEASE TABLET AND ITS COMPARISON WITH MARKET PRODUCT
In this study, an attempt was made to design and evaluate oral sustained release matrix tablets of ciprofloxacin using methocel K4M CR, HPMC 15 cps, avicel PH 101 as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability, and drug content. All the formulations showed compliance wit...