Posted by admin on Oct 31, 2019 in |
Yellow oleander is an important medicinal material in Mexican traditional medicine. In early times it is assumed that all parts of the oleander plant are poisonous to humans, animals, and certain insects but now a day’s numbers of pharmacological activities are determined by different scientists. For containing cardiac glycoside this plant is mostly not non-toxic. However, this plant has many pharmacological properties such as antidiarrhoeal activity, cytotoxic activity, antimicrobial activity, anticancer activity. This paper explains the evidence-based information regarding the phytochemistry and pharmacological activity of this...
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Posted by admin on Oct 31, 2019 in |
Mandragora officinarum (MO) is thought to be one of the magical herbs since the classical period. The plant belongs to the Solanaceae family and popular in Greeks, the Romans, the Arabs and Hebrews. Earlier, it was believed that the plant has evil power. Different ethnic groups worked closely to establish its profound benefits in the traditional medical field. After thorough research on this plant, it was found that the plant has several medicinal properties and has a powerful intoxicating nature. Even, it is familiar for its narcotic and anesthetic characteristics. Not only that the plant can be used in hallucination, but mania, delirium and can also relieve certain joint pains and acts as a healing agent. It’s diversified phytochemistry consisting of alkaloids, nonalkaloids and some sugars. The current article demonstrates its several pharmacological benefits such as narcosis, anesthetic, aphrodisiac, natural healer and hallucinating quality along with its different phytochemical constituents like atropine, hyoscyamine, cuscohygrine, scopolamine, belladonine, some...
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Posted by admin on Sep 30, 2018 in |
Diabetes is a metabolic disorder of the endocrine system. The medicinal plant has used for the treatment of diabetes throughout the world. Several medicinal plants are known to treat diabetes, and they have no side effect. The medicinal plant performed a good clinical practice and is showing a bright future in the treatment of diabetes mellitus. Many studies have confirmed the benefits of the medicinal plant with a hypoglycemic effect in the management of diabetes mellitus. This present review evaluates the medicinal plant used for anti-diabetic activity. The present review profile gives information about the plant’s scientific name, common name, family, and the part of the plant used to treat diabetes...
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Posted by admin on Aug 30, 2018 in |
Cancer is a general term applied to a series of malignant diseases that may affect different parts of the body. Cancer is a disease which occurs when changes in a group of normal cells within the body lead to uncontrolled growth causing a lump called a tumor; this is true of all cancers except leukemia (cancer of the blood). When cancer spreads to other parts of the body, this is called metastasis. Methotrexate (MTX) is a folate antimetabolite used as an anticancer agent in the treatment of head and neck cancer, lung cancer, breast cancer. The doses and frequency of administration of MTX depend on its toxicity to hematopoietic tissues and buccal or gastrointestinal mucosa, drug resistance, leucopenia, and nephrotoxicity and limits its chemotherapeutic applications. Methotrexate is an antineoplastic antimetabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the “S” phase (of the cell cycle), stopping normal development and division. Methotrexate is also...
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Posted by admin on Jan 13, 2018 in |
The relentlessly beating heart has the greatest oxygen consumption of any organ in the body at rest, reflecting its huge metabolic turnover and energetic demands. The vast majority of its energy is produced and cycled in the form of ATP which stems mainly from oxidative phosphorylation occurring at the respiratory chain in the mitochondria. A part of energy production, the respiratory chain is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the respiratory chain is therefore found in most common heart conditions. The pathophysiology of mitochondrial respiratory chain dysfunction in hereditary cardiac mitochondrial disease, the aging heart, in LV hypertrophy and heart failure, and ischemia-reperfusion injury is reviewed. We introduce the practicing clinician to the complex physiology of the respiratory chain, highlight its impact on common cardiac disorders, and review translational pharmacological and non-pharmacological treatment...
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