A REVIEW ON SYNTHESIS, CHARACTERISATION AND BIOLOGICAL SCREENING OF NOVEL INDOLE DERIVATIVES FOR CERTAIN PHARMACOLOGICAL ACTIVITESAbstract
Indole derivatives are prepared by heating a mixture of ketone and phenylhydrazine for 1 hour in a water bath. Poured the heated mixture to a flask and added previously boiled acid to it and again heated and stirred for an additional 10 min. Added the mixture to 25 ml of ice water. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, and resistance to drugs, biofilm formation, and virulence. Indole derivatives show antimicrobial, antidepressant, anticonvulsant, anti-inflammatory, and analgesic activities.
M. George, L. Joseph and A. M. Thomas*
Department of Pharmacology, Pushpagiri College of Pharmacy, Thiruvalla, Kerala, India.
11 January 2017
12 March 2017
21 March 2017
31 March 2017