BENEFITS AND RISKS OF FLUOROQUINOLONES USE IN PEDIATRICS: A REVIEWAbstract
Fluoroquinolones are synthetic fluorinated derivatives of nalidixic acid and are an important group of antibacterials along with the beta-lactam and macrolides are used for the treatment of various infectious diseases in adults; however, their use in children has been limited as the result of fluoroquinolone-induced musculoskeletal toxicity in animal studies. Those antibiotics are useful in the treatment of cystic fibrosis, urinary tract infections, neutropenia, gastrointestinal infections, meningitis with resistant bacteria, chronic suppurative otitis media, some cases of complicated acute otitis media, conjunctivitis, infections caused by Enterobacteriaceae (including the neonatal period), some mycobacterial infections, prophylaxis of anthrax and sepsis caused by other antibiotic-resistant organisms in pediatrics. Most of the available human studies showed the incidence of a musculoskeletal adverse event is relatively higher in fluoroquinolones than nonfluoroquinolone antibiotics; however, almost all AEs are reversible and transient. Hence, fluoroquinolones can be clinically considered in children when the benefit outweighs the possible risk.
A. kahsu *, T. Aklilu, B. Masresh and W. Melkam
Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
21 January 2015
22 March 2015
28 April 2015
01 May 2015