ETHOSOMES NOVEL DRUG DELIVERYAbstract
Transdermal drug delivery system was first introduced more than 30 years ago. The technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes; hence, these can be used widely in place of liposomes. Ethosomes have become an area of research interest because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency, etc. The purpose of writing this review on ethosomes drug delivery was to compile the focus on the various aspects of ethosomes including their mechanism of penetration, preparation, advantages, composition, characterization, application and ethosomes. Characterizations of ethosomes include particle size, zeta potential, Differential Scanning Calorimetry, entrapment efficiency, surface tension activity measurement, vesicle stability, and penetration studies, etc.
P. A. Gangurde *, R. B. Saudagar
Department of Quality Assurance and Techniques, KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Trimbakeshwar, Nashik, Maharashtra, India
13 November 2016
23 January 2017
29 January 2017
31 January 2017