FORMULATION AND EVALUATION OF DELAYED RELEASE TABLETS OF PALIPERIDONEAbstract
Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. The present research work was an attempt to formulate and evaluate paliperidone delayed-release tablets. A combination of hydroxypropyl methylcellulose (HPMC K100M) and polyvinyl acetate phthalate, cellulose acetate phthalate were used as polymers. The tablets were prepared by direct compression method. 12 formulations were prepared by changing the ratios of the drug and polymer to study the effect of variable concentrations of polymers and characteristics of the tablets. The prepared tablets were evaluated by different parameters such as Thickness, weight variation, hardness, content uniformity. The tablets were also evaluated for in vitro drug release in 0.1N HCl for 12 h in USP Type II dissolution apparatus. Among all the formulations (F-I to F-XII) prepared, batch F-12 gave good results of Paliperidone when compared to other formulations. Hence, formulation F12 was found to be equivalent to a marketed product with good bioavailability properties. It also showed no significant change in physical appearance and drug content.
G. Vijendhar, C. Swethaa and K. Mohini
Chilkur Balaji College of pharmacy, Aziznagar Post Moinabad Road, Hyderabad, Andhra Pradesh, India.
09 November 2014
03 January 2015
28 January 2015
01 February 2015