FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF AMLODIPINE BESYLATE USING DIFFERENT SUPERDISINTEGRANTS CONTAINING SOLID DISPERSION BY DIRECT COMPRESSION METHODAbstract
Amlodipine besylate is a major calcium channel blocker for the treatment of hypertension. Solid dispersion Amlodipine besylate (SD-AB) was prepared by using EC, HPMC, and croscarmellose in different ratios. The development of rapidly disintegrating oral tablets of Amlodipine besylate by direct compression method. The tablets were prepared by using direct compression method and evaluated for weight variations, hardness, friability, wetting time, disintegration time, and dissolution study. Although oral disintegrating tablets are much useful in the cases of the geriatric, pediatric, and traveling patient because of no water required for the administration, therefore, the solid dispersions prepared by a solvent evaporation method using EC, HPMC and croscarmellose carrier can be successfully used for the improvement of dissolution of SD-AB and resulted in a faster onset of action as indicated by in-vivo studies.
J. Verma *, S. K. Prajapati, D. K. Chanchal, R. K. Bijauliya and N. Agnihotri
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
08 February 2018
25 March 2018
15 April 2018
30 April 2018