FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET WITH TASTE MASKING RESINAbstract
Mouth dissolving tablet disintegrates within a minute without drinking water. The purpose of present work was to develop a patient-friendly tablet for antihypertensive treatment using Benazepril HCl was taste masked by complexing with indion 204 and formulate as mouth dissolving tablet (MDT). The formulated drug-resin complex was characterized by IR, DSC, etc. Overall nine mouth dissolving formulations were prepared by direct compression method using three different superdisintegrants viz. croscarmellose sodium, sodium starch glycolate, and crospovidone. The tablets disintegrated in-vitro within 20 s, and the complex drug was released from tablet within 3 min. Formulation F1 to F3 were prepared by direct compression method using sodium starch glycolate as superdisintegrants was found to release the drug in the range of 88.20 to 91.98%. Similarly, formulation F4 to F6, which were prepared by using crospovidone as superdisintegrants showed maximum percent drug release, i.e. 88.27 to 92.68%. Further, F7 to F9 were prepared by using croscarmellose sodium as superdisintegrants and showed percent drug release between 87.72 to 89.18% range. Studies indicated that F4 was found to be best among all other formulations because it has exhibited faster wetting time, good taste, and faster disintegration time when compared to all other formulations.
G. R. Godge *, A. V. Misal and P. Y. Pawar
P.D.V.V.P. Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar, Maharashtra, India.
28 June 2015
28 July 2015
29 July 2015
31 July 2015