FORMULATION AND PERFORMANCE EVALUATION OF ESCITALOPRAM LOADED BIO-NANO SUSPENSION USING A NOVEL BIO-RETARDENT FROM PIPER NIGRUM

Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore a novelistic route for targeting to the brain through the ear by formulating nanosuspension using Escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardiovascular diseases. The delivery has overcome the dose dumping problem in case of the oral system. In this research work, significant effort was made to explore the novelistic platform for the ear to the brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 h. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having an r² value of 0.9905 t 80: 22 h and best-fit model was found to be Higuchi matrix, and mechanism of transport was anomalous transport which was calculated by bits software.  According to the in-vitro results obtained, it can be concluded that a significant amount of drug reaches the brain via external acoustic meatus. The demand for curbing depression and other mental health conditions is on the rise globally. Nanosuspensions are a distinctive and commercially feasible approach to solve the problems of a hydrophobic drug such as poor solubility and poor bioavailability.