FORMULATION AND PREPARATION OF TRANSDERMAL PATCHES OF GLIMIPRIDE (PART -1)Abstract
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use, and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half-life of ~ 5 h, low bioavailability, and extensive first-pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as a transdermal drug delivery system. The present study was to formulate and evaluate the transdermal drug delivery system of Glimepiride using polymers such as tristearin, soya lecithin & Eudragit RS100 by solvent casting technique. Central composite design (CCD) was applied by using design-expert to optimize the composition of tristearin and soya lecithin for transdermal drug delivery. The prepared formulations were evaluated for different physicochemical characteristics like weight variation, folding endurance, flatness, pH of patches, % moisture content, % moisture uptake, % elongation, % drug content and % drug release.
R. Sonkar *, S. K. Prajapati, R. K. Bijauliya, D. K. Chanchal and P. K. Singh
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
19 June 2018
23 July 2018
29 July 2018
01 August 2018