FORMULATION AND PREPARATION OF TRANSDERMAL PATCHES OF GLIMIPRIDE PART -2Abstract
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use, and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half-life of ~5 h, low bioavailability, and extensive first-pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as a transdermal drug delivery system. To formulate and evaluate the transdermal drug delivery system of Glimepiride using polymers such as tristearin, soya lecithin, and Eudragit RS100 by solvent casting technique. Formulation of transdermal patches of glimepiride and optimization of SLN transdermal patches. Central composite design (CCD) was applied by using design-expert to optimize the composition of tristearin and soya lecithin for transdermal drug delivery. Prepared drug loaded SLNs were evaluated for particle size analysis, DSC, Drug entrapment efficiency, SEM, and in-vitro release studies. The present study of formulation and preparation of transdermal patches of Glimipride to provide better efficiency of drug another dosage form.
R. Sonkar *, S. K. Prajapati, R. K. Bijauliya, D. K, Chanchal and P. K. Singh
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
09 September 2018
05 October 2018
25 October 2018
01 November 2018