FORMULATION, DEVELOPMENT AND CHARACTERISATION OF MICROEMULSION SYSTEM OF AMOXICILLINAbstract
Present study aimed to develop a microemulsion system for topical application of Amoxicillin to provide various advantages over conventional dosage forms. Amoxicillin is broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clavulanic acid (a beta-lactamase inhibitor) as it is susceptible to beta-lactamase degradation. Clinical studies show that it is highly effective for topical treatment of skin infections. The microemulsion was prepared using oleic acid as an oil phase, tween 20 as surfactant and propylene glycol as co-surfactant. The drug was evaluated for their micropolitical properties like the angle of repose, bulk density; tapped density, Carr’s index, and Hausner’s ratio were studied. In-vitro characterization of the microemulsion of amoxicillin was done through measurement of pH, conductivity, viscosity, drug stability.
A. Rastogi *, R. N. Prajapati, S. K. Prajapati, R. K. Bijauliya, D. K. Chanchal and S. Kumar
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
06 February 2018
20 August 2018
28 August 2018
01 September 2018