GENE PATHWAYS IN CANCER: BEGINNING, ENDING AND THE ACTORS OF THE STORYAbstract
The advancements of cancer research if put in a nutshell can be described as: “Cancer is a genetic disease.” From the past two decades, several actors for cancer are identified, their mutations are characterized, and the pathways they control are described. Intricate relations among JAK-STAT, TGF-B, MAPK, Ras, Wnt, Notch, and Hedgehog signaling pathway have a vital role in apoptosis, survival, proliferation, and differentiation. Dysregulation of these pathways due to driver mutations are often found involved in the growth of cancer. The purpose of this review is to enlighten the advancement in these areas of cancer, specify where there is room for research, and provide a potential base for future research.
M. J. Ul-Hasnain *, T. Anwar, B. Afzal, H. M. T. Malik and S. H. Abbas
Department of Bioinformatics, Virtual University of Pakistan, D-102, Satellite Town, Rawalpindi, Pakistan.
08 February 2018
18 March 2018
28 March 2018
31 March 2018