GENETIC ENGINEERING TECHNIQUE: AN EFFECTIVE APPROACH FOR WOUND INFECTION MANAGEMENT

Infection is the major problems in a diabetic patient where the healing process are slow down and increases complications. Antiseptics helps to limit the growth of unwanted bacteria (opportunistic pathogen) superficially but do not work in case of deeper infection as its mode of action slows down after some time. The use of antibiotics also emerges multi-drug resistant pathogens, which are considered more dangerous and difficult to treat. Therefore, a new approach to wound therapy is expected that can escape many of the problems associated with current antibiotic treatments. In this regards, genetically engineered bacteria and their products may enhance the natural wound healing process. Wound healing factors like growth factors as well as fibroblast can be incorporated into bacteria genome which will promote healing mechanism speedily. In this aspect, modified bacteria will also prevent the unnecessary growth of the opportunistic pathogen. Many advantages are anticipated from the use of genetically modified organism and its products in wound treatment. The present review is focussed on the various approach of genetic engineering technique in effective wound healing and wound infection treatment.