LIPID BASED DRUG DELIVERY SYSTEM: A REVIEWAbstract
Poor solubility remains one of the more challenging and critical tasks in drug discovery and development, and it is also the main cause of low bioavailability and poor therapeutic efficacy of the drug. Many solubility enhancement techniques are available in literature like cyclodextrin inclusion complexes, salt formation, solid dispersion, drug delivery carrier approach and prodrug approach are useful, but the most widely used technique for enhancing the solubility of poorly soluble drugs is by encapsulating the drug is lipid-based excipients, which enhances solubilization of the drug in excipient matrix, lead to enhanced bioavailability and improved therapeutic efficacy. Many lipid-based drug delivery systems are available like self-emulsifying drug delivery system (SEDDS), liposomes, solid lipid nanoparticles, nanostructured lipid carrier, which are widely used for lipophilic drugs. In this review, we highlighted some novel mechanisms for drug absorption through lipid-based systems and its commercial applications in the pharmaceutical and biological field.