NANOSUSPENSIONS: A PROMISING DRUG DELIVERY STRATEGYAbstract
Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving the bioavailability of several drugs with low solubility. A formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs, which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of the drug and thus improves drug safety and efficacy. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in-vitro and in-vivo applications by various routes: parenteral, oral, pulmonary, and topical. They have also been used for drug targeting. Different preparation methods for Nanosuspensions and their application are being reported and patented. The number of products based on nanosuspension in the market and under clinical study is higher than that of other nanotechnology-based applications.
Afrin *, S. K. Prajapati, D. K. Chanchal, N. Agnihotri, S. Tiwari, D. Singh and C. Ali
Department of Pharmacy, Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India.
30 April 2019
23 May 2019
21 June 2019
30 June 2019