NUTRACEUTICAL FORMULATION OF GROUNDNUT OIL CAKE AND STUDY OF DRUG RELEASE AT VARIOUS pHAbstract
The drug discovery and computational advances have helped chemists to develop drugs having utility for specific functional applications along with nutritional aspects. This enables researchers to design formulations and synthesized proper medicines as nutrients. Preparation of nutraceutical formulation that to a veterinary formulation is one of the challenging tasks. Various types of formulations have been devised for sustainable release, easier dissolution with no side effects, and target specific delivery of the chosen drug. The oral administration of veterinary drugs is one of the difficult task, particularly the formulation with the disagreeable smell, taste as well as low nutritional value. Considering these, it was planned to develop easy and likable preparation of nutraceutical formulation of the veterinary drug for easy oral delivery, comprising sustain release of the drug. In the present report, discussion of the formulation of ketoprofen in which veterinary drug is incorporated along with the groundnut or cottonseed oil cake through adsorption method of formulation preparation. Such a formulation can be assimilated effectively by ruminants as the oil cakes are liked by animals, as well contains a very good amount of fat-producing nutrients. The prepared formulation was characterized by FTIR, FESEM, TGA techniques, and the studies related to the release rate of the drug were made using the spectrophotometric technique. The detail about the formulation and other related studies are presented and discussed.
D. S. Agrawal, D. K. Patil, R. R. Mahire and D. H. More *
School of Chemical Science, North Maharashtra University, Jalgaon, Maharashtra, India.
10 December 2015
05 February 2016
24 February 2016
29 February 2016