PAMAM DENDRIMER MEDIATED FORMULATION, DEVELOPMENT AND CHARACTERIZATION OF FLURBIPROFENAbstract
The aim of the present study was comprehensively establishing the utility of PAMAM dendrimers in solubility enhancement of Flurbiprofen. It can be concluded that PAMAM dendrimers in the solubility of Flurbiprofen but also helped to localize the drug at the site of action and the drug can provide better therapeutic efficacy with lower dose by reducing its adverse effect. From the solubilization study, it was observed that the increase in solubility was due to the dendrimeric complexation or encapsulation. From this paper, it can also be concluded that formulation containing more amount of dendrimer concentration provides a higher flux than formulation containing a lower amount of dendrimer. This may be due to an increased thermodynamic activity of the drug in dendrimic formulation at a lower concentration of dendrimer.
N. Singh *, D. Singh, R. N. Prajapati and S. K. Prajapati
Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
10 June 2019
12 July 2019
28 July 2019
31 August 2019