PHYTOCHEMICAL AND PHARMACOLOGICAL SCREENING OF THE FRUITS OF LAGERSTROEMIA SPECIOSA (L.) PERSAbstract
The present study was investigated the phytochemical properties, analgesic and cytotoxic activities of the ethanolic extract of Lagerstroemia speciosa (L.) Pers. fruits (Family-Lythraceae). Phytochemical screening of the ethanol extract of fruits of L. speciosa showed the presence of Steroids, Tannins, and Saponins types of compounds. The pharmacological interest of these compounds encouraged to check L. speciosa Pers. for possible analgesic & cytotoxic activities. The crude extract at the dose of 500 mg/kg body weight exhibited moderate action against acetic acid-induced pain in mice significantly (p<0.01), where percentage of protection was found 55.21% while the standard drug diclofenac’s percent of protection was found to be 84.37% at a dose of 25 mg/kg body weight. The extract showed potent cytotoxic activity to brine shrimp, and LC90 was found at the dose of 100 µg/ml as well as LC50 was 60 µg/ml. The obtained results must help use this plant in traditional medicine and its further investigation.
S. F. Bellah *, K. R. Islam, M. R. Karim, M. Ashrafudoulla and M. Hasan
Depertment of Pharmacy , Manarat International University, Dhaka, Bangladesh.
21 February 2016
25 March 2016
05 April 2016
30 April 2016