STUDY OF DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE GLIPIZIDE BY USING SOLID DISPERSION TECHNIQUEAbstract
The aim of the present research work is to design and evaluate controlled release transdermal patches of selected cardiovascular drug Atenolol. To optimize the prepared formulations by different trial approaches. To design and formulate transdermal patch of Atenolol by mercury substrate method using a few selected polymers viz., HPMC, PVP, EVA, Eudragit RS and RL100 in various proportions and Di-n-butyl Phthalate for the release retardant controlled release transdermal patch. Atenolol was chosen as a model drug for study since it possesses near ideal characteristic that a drug must have in formulating a drug delivery system such as low molecular weight, high lipid solubility, effective in low plasma concentration. It also means multiple administrations with subsequent lack of patient compliance.
M. S. Mondal *, M. H. Emon, Sharif M. Abuzar, M. A. Islam, M. T. Islam and M. A. Islam
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh.
23 February 2015
29 March 2015
28 April 2015
01 May 2015