SUSTAIN RELEASE FORMULATION AND EVALUATION OF CIPROFLOXACIN SUSTAIN RELEASE TABLET AND ITS COMPARISON WITH MARKET PRODUCTAbstract
In this study, an attempt was made to design and evaluate oral sustained release matrix tablets of ciprofloxacin using methocel K4M CR, HPMC 15 cps, avicel PH 101 as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability, and drug content. All the formulations showed compliance with pharmacopeial standards. In vitro release studies were performed using USP type II apparatus (paddle method) in 900 ml of 0.1N HCl at 50 rpm for 8 h. The release kinetics was analyzed using the zero-order, first order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations to explore and explain the mechanism of drug release from the matrix tablets. In vitro release studies revealed that percent drug release decreased with increase of polymer loading. Based on the dissolution data comparison with innovator brand F-5 formulation (16% Methocel K4M CR w/w of drug) was elected as the best formulation. The drug release profile of the best formulation was well controlled and uniform throughout the dissolution studies.
M. S. Mondal*, S. M. Abuzar, M. A. Islam, M. T. Islam and M. S. Rahman
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh
25 January 2015
17 March 2015
28 March 2015
01 April 2015