THE ANALYSIS OF BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN PSYCHIATRIC PATIENTS WITH A HISTORY OF IV DRUG ABUSE, ADDICTION AND HEPATITIS C IN AHVAZ CITY DURING 2012 – 2015Abstract
Contaminated injection equipment have a pivotal role in the spread of HCV infection. IV drug users are one of the populations with a high risk of HCV infection. Objectives: our goal was to evaluate the role of a hazardous action (intravenous injection with contaminated equipment) in threat of public health. In this study, we collected data on 37 psychiatric patients with a history of IV drug abuse and addiction with HCV and compared to psychiatric patients with a history of IV drug abuse without HCV. Here was measured biochemical and hematological parameters and analyzed by SPSS. We found levels of AST and ALT significantly increased, but ALP and albumin none significantly decreased in patients (p≤0.05). Moreover, PT, aPTT, and ESR levels in patients were slightly higher than the control group. Also, a significant correlation between AST and ALT to serum creatinine in patients may indicate a relationship between kidney problems followed by hepatic damage. The mean value of FBS, Tg, and cholesterol levels was nearly similar in both groups. The serum level of calcium and phosphate in patients were significantly lower and higher than the control group, respectively (p≤0.05). There were a reduction and increment in serum level of free T3 and free T4 respectively, and the level of TSH in patients was nearly 3 times higher than the control group. Thus, primary hypothyroidism has seemed in the patients. Finally, we concluded the evaluation of IV drug abuser for the prognosis of HCV widespread is very important.
S. H. Hassanpour * and S. Z. Karami
Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
11 May 2017
19 June 2017
23 June 2017
30 June 2017