TRANSDERMAL DRUG DELIVERY BY SONOBANDAGE: A MINI REVIEWAbstract
Over the last decade, the public has become increasingly aware of the potentially dangerous, systemic side effects of pain medication. Even readily available over-the-counter drugs like acetaminophen, ibuprofen, and aspirin can cause serious damage to the digestive system as a result of long term usage and/or high dosage. A possible alternative to pills for pain relief is transdermal drug delivery, the transfer of drugs across the skin. Transdermal delivery has the advantage of keeping the drug in the area where it is applied, allowing for a reduced total dose compared to a pill, but there are challenges with the method. The skin evolved as a highly efficient barrier to keep foreign substances out. After a drug gets through the skin, there is the problem of assuring drug is delivered evenly in an effective dose. Current transdermal drug delivery methods such as aspirin creams use chemical enhancers to allow the drugs to pass through the skin. The amount of aspirin that is absorbed by the body is still limited, however, and may not provide adequate pain relief. Faced with these challenges, there is a great deal of interest in researching new drug delivery methods for pain relief, which are administered locally and may not have the same systemic side effects as oral medications.
P. Kant *, N. K. Navani, R. K. Bijauliya and D. K. Chanchal
Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
08 September 2018
03 October 2018
23 October 2018
01 November 2018