Posted by admin on Dec 31, 2019 in |
We earlier established the anti-secretory and mucogenic activities of tadalafil in indomethacin induced ulceration in rats and that these properties are modulated by the presence of sex hormones and thyroxine. The current study investigated the influence of these hormones on gastric blood flow, prostaglandin secretion and nitric oxide production in rats. Adult Wistar rats (140-160 g) were used. Gastric ulcer was induced in fasted rats using oral indomethacin (40 mg/Kg). Direct gastric blood flow was measured with a transonic T206 blood flow meter. Animals were sacrificed 4 h after ulcer induction. ELISA technique was used to evaluate the concentration of prostaglandin E2 (PGE2) and nitrite in the gastric homogenate. Data were analysed by ANOVA followed by Newman Keul’s post-hoc test at α0.05. Blood flow, gastric PGE2 and nitric oxide contents were significantly elevated by tadalafil and by co-administration of tadalafil with oestrogen or thyroxine. We conclude that the gastro protective effect of tadalafil was mediated by increased PGE2 and nitric oxide generation and that this protective effect is enhanced...
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Posted by admin on Dec 31, 2019 in |
Prader-Willi Syndrome (PWS) is a rare genetic disorder. It causes poor muscle tone, low degrees of sex hormones, and consistent sentiment of craving. The piece of cerebrum that controls yearning does not work appropriately in individuals with PWS. The gorge, prompting weight. There is no remedy for PWS exercise and dietary supervision can help fabricate bulk and control weight. le with PWS need particular consideration and supervision for the duration of their lives. The information is gathered from the PubMed database utilizing watchword search from the year 2009 to 2018 absolutely for a long time; the gathered information is masterminded in exceed expectations position for simple examination. Aggregate of 1381 writing is distributed from the year 2009 to 2018; in the year 2016, the most elevated number of 172 articles are distributed. In the year 2015, an aggregate of 154 articles distributed, and in the year 2018, an aggregate of 145 articles distributed. A minimal number of articles distributed in the year 2009 aggregate of 107. Origin example uncovers...
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Posted by admin on Nov 30, 2019 in |
In the present study, four different groundnut varieties such as RS-1 (Rs-1), TAG-3a (Tg-3a), TAG-51 (Tg-51), and TAG-24 (Tg-24) were grown under different geographical places in India. Physicochemical properties of collected groundnut seeds and their extracted oils were determined for their nutritional assay. It was found that the seeds contained in the range of extracted oil, the specific gravity, viscosities, impurities, refractive index and color of the extracted groundnut seed oil were in the range of 39.98-41.9 (±0.4837) 0.9154-0.9164 (± 0.000), 91.56-91.64 (± 0.0365), 0.03-0.05 (± 0.0085), 1.4633-1.4639 (± 0.000) and 1.24-2.2 (± 0.4313) yellow units respectively. AV (mg KOH/g oil), IV (g I2/100 g oil), SV (mg KOH/ g oil), ester value and unsaponifiable matter content (%) of the extracted oil from groundnut seeds were in the range of 2.33-3.38 (± 0.4837), 91.37-93.65 (± 0.9468), 191.0-193.99 (±1.3588), 187.67-191.67 (± 1.9574) and 0.52-0.63 % (± 0.0466) respectively. This study is empirical and on the basis of finding it revealed that groundnut seed oil could be a valuable source of...
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Posted by admin on Nov 30, 2019 in |
We provide evidence of the structural development and distributional pattern of polysaccharides of the anthers in Melia azedarach L. The anthers of Melia azedarach L. is tetrasporangiate and basic type of wall formation is seen, it consists of six wall layers i.e. single layer of epidermis and endothecium, three middle wall layers and one tapetal layer. The primordium consists of a homogenous mass of meristematic cells which has a uniform distribution of insoluble polysaccharides. Sporogenous cells are moderate with PAS-positive and starch grains are present in all the wall layers. Meiocyte shows a moderate amount of carbohydrate with a prominent nucleus. The secretory cells are present near the connective and tapetum. Secretary cells are having abundant starch grains. Tetrahedral tetrads are present with surrounding thick callose walls with rich PAS-positive walls. The secretary type of tapetum is initially single-layered but some of the cells divide periclinally so that it becomes two-layered at vacuolated microspore stage. Middle wall layers are starting to degenerate at the tetrad stage. The pollen grains...
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Posted by admin on Oct 31, 2019 in |
Mandragora officinarum (MO) is thought to be one of the magical herbs since the classical period. The plant belongs to the Solanaceae family and popular in Greeks, the Romans, the Arabs and Hebrews. Earlier, it was believed that the plant has evil power. Different ethnic groups worked closely to establish its profound benefits in the traditional medical field. After thorough research on this plant, it was found that the plant has several medicinal properties and has a powerful intoxicating nature. Even, it is familiar for its narcotic and anesthetic characteristics. Not only that the plant can be used in hallucination, but mania, delirium and can also relieve certain joint pains and acts as a healing agent. It’s diversified phytochemistry consisting of alkaloids, nonalkaloids and some sugars. The current article demonstrates its several pharmacological benefits such as narcosis, anesthetic, aphrodisiac, natural healer and hallucinating quality along with its different phytochemical constituents like atropine, hyoscyamine, cuscohygrine, scopolamine, belladonine, some...
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