Posted by admin on Sep 30, 2018 in |
Diabetes is a metabolic disorder of the endocrine system. The medicinal plant has used for the treatment of diabetes throughout the world. Several medicinal plants are known to treat diabetes, and they have no side effect. The medicinal plant performed a good clinical practice and is showing a bright future in the treatment of diabetes mellitus. Many studies have confirmed the benefits of the medicinal plant with a hypoglycemic effect in the management of diabetes mellitus. This present review evaluates the medicinal plant used for anti-diabetic activity. The present review profile gives information about the plant’s scientific name, common name, family, and the part of the plant used to treat diabetes...
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Posted by admin on Aug 31, 2018 in |
Guar gum is a non-ionic polysaccharide that is found abundantly in nature. It is extracted from the endosperm of seeds of guar plant (Cyamopsis tetragonaloba). It has many advantageous applications in industries due to their various properties. Guar gum is widely used in cosmetics, food, paper, textile, explosive, and pharmaceutical industry. In pharmaceuticals, the use of guar gum as delivery carriers as drugs has gained great attention due to its high swelling characteristics in aqueous solution. Guar gum can be modified by derivatization, grafting, and network formation to improve its property profile for a wide spectrum of biomedical applications. Guar gum and its derivatives in the various forms such as coatings, matrix tablets, hydrogels, and nano/microparticles are exploited as potential carriers for targeted drug delivery, colon-specific, protein, transdermal drug delivery systems. Guar gum is also used for healthy bowel activity, weight loss, and diabetes control. Partially hydrolyzed guar gum (PHGG) is produced by a controlled process of partial hydrolysis. PHGG affects the prevention and treatment of constipation, diarrhea, diabetes,...
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Posted by admin on Aug 30, 2018 in |
Cancer is a general term applied to a series of malignant diseases that may affect different parts of the body. Cancer is a disease which occurs when changes in a group of normal cells within the body lead to uncontrolled growth causing a lump called a tumor; this is true of all cancers except leukemia (cancer of the blood). When cancer spreads to other parts of the body, this is called metastasis. Methotrexate (MTX) is a folate antimetabolite used as an anticancer agent in the treatment of head and neck cancer, lung cancer, breast cancer. The doses and frequency of administration of MTX depend on its toxicity to hematopoietic tissues and buccal or gastrointestinal mucosa, drug resistance, leucopenia, and nephrotoxicity and limits its chemotherapeutic applications. Methotrexate is an antineoplastic antimetabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the “S” phase (of the cell cycle), stopping normal development and division. Methotrexate is also...
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Posted by admin on May 31, 2018 in |
The purpose of the current review is to enlighten the present and the future perspective on oral fast dissolving films (OFDFs) as a drug delivery system as they are gaining interest as a substitute of fast dissolving tablets. Tablets/capsules to modified release tablets/capsules to oral disintegrating tablet to wafer to the recent development of fast dissolving oral films. Fast dissolving drug delivery systems were first invented in the late 1970s to overcome swallowing difficulties associated with tablets and capsules for pediatric and geriatric patients. Also, solid oral delivery systems do not require sterile conditions and are therefore less expensive to manufacture, but oral drug delivery systems still need some advancements to be made because of their drawbacks related to particular class of patients which includes geriatric, pediatric and dysphagia patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking because of tablet appearance, and patients experienced...
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Posted by admin on Apr 30, 2018 in |
Transdermal drug delivery system was introduced to overcome the difficulties of drug delivery through the oral route. Despite their relatively higher costs, transdermal delivery systems have proved advantageous for delivery of selected drugs, such as estrogens, testosterone, clonidine, and nitro-glycerine. Transdermal delivery provides a leading edge over injectable and oral routes by increasing patient compliance and avoiding the first-pass metabolism, respectively. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Skin is an effective medium from which absorption of the drug takes place and enters into systematic circulation over some time. The present article reviews the selection of drug and polymers suitable to be formulated as a transdermal system, advantages, disadvantages of formulation design, and the methods of preparation and evaluation of...
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