Posted by admin on Jun 30, 2019 in |
Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving the bioavailability of several drugs with low solubility. A formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs, which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of the drug and thus improves drug safety and efficacy. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in-vitro and in-vivo applications by various routes: parenteral, oral,...
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Posted by admin on Apr 30, 2019 in |
Sida cordifolia is locally known as Bala is one of those precious medicinal herbs of Malvaceae that are still included in un-utilized herbs in spite of the variety of useful pharmacological properties it possesses. Sida cordifolia have anti-inflammatory, anti-ulcer, anti-diabetic, nephroprotective, cytotoxicity, anti-hypercholesterolemia, hepatoprotective, analgesic, anti-stress and adaptogenic activity, cardiovascular, anticancer, antibacterial, antimelanogenesis, anticandidal activity, anti-parkinson’s disease, CNS depressant, fat loss, hypotensive, ultrastructure and antioxidant properties. Here, we have reviewed all the reported pharmacological properties and phytoconstituents of this valuable herb to highlight the effectiveness and potentials of this...
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Posted by admin on Apr 30, 2019 in |
Mikania cordata which belongs to the family Asteraceae is a medicinal plant that has been widely distributed through Southeast Asia and Eastern Africa. It possesses various therapeutic properties which include – anti-inflammatory, anti-ulcer, bronco-dilating, analgesic, antibiotic, anti-diarrheal, hepatoprotective, epidermal or skin protective, coagulative, anticarcinogenic, CNS depressant, anti-stress, cytotoxic, insect and scorpion bites and so on. As per from our study, there is no other review paper available till now regarding the pharmacological properties of this plant. Therefore, our paper is the first one to report a review on Mikania cordata. In this paper, along with the pharmacological properties, the other necessary features regarding the plant can be well acknowledged and can be utilized for further research and study...
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Posted by admin on Mar 31, 2019 in |
The buccal cavity is considering as a door for the digestive system. It is composed of teeth, tongue, and palate. When the food enters the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine, and anal opening. When the drug is taken by the buccal delivery system, it decreases the time needed for the drug to give its action, progresses the therapeutic action of the drug and gives a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, pre-systemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and gives response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and...
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Posted by admin on Feb 28, 2019 in |
Nanoemulsions have attracted great attention in research, dosage form design, and pharmacotherapy. This is as a result of some attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, thermodynamic stability and increased surface area. Poor water solubility remains the main culprit for the formulation scientist which can be overcome by canonization. Nanoemulsion is a kinetically stable and isotropic system of two immiscible liquids in the submicron size range. Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Many parenteral nutrition and drug emulsions on the market confirm the safe use of NE over the years. Parenteral emulsions loaded with APIs (active pharmaceutical ingredients) are considered as drug delivery systems (DDS). DDS focuses on the regulation of the in-vivo dynamics, such as absorption, distribution, metabolism, and extended bioavailability, thereby improving the effectiveness and the safety of the drugs. Nanoemulsion is the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase using...
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