Posted by admin on Dec 17, 2015 in |
Several liquid crystalline phases are bicontinuous cubic, reversed hexagonally, or reversed cubic phase, and several nanostructure liquid phases. Of the many liquid crystalline phases, bicontinuous cubic phases possess a special status. Dispersed particles of bicontinuous cubic liquid crystalline phase (cubosomes) are self-assembled nanostructured particles that can be formed in aqueous lipid and surfactant systems. Cubosome dispersions are thermodynamically stable, bioadhesive, and biocompatible, because of their properties, they are versatile systems, administrable by different ways such as orally, percutaneously, and parenterally. The discovery of cubosomes is a unique story. Despite the early realization of their potential, the manufacture of cubosomes on a large scale faced difficulty because of their complex phase behavior and viscous properties. The cubosome advantage is related to the simple production procedure and chemico-physical stability. Concerning the liposome, cubosome possesses a larger ratio between the bilayer area and the particle volume and larger breaking resistance. Cubosome structure studied using electron microscopy, “light scattering,” x-ray and “NMR.” This review focus on liquid crystalline phase and cubosomes (bicontinuous cubic...
Read More
Posted by admin on Dec 13, 2015 in |
This prescription survey was carried out to find the most frequently used benzodiazepine class (e.g., Clonazepam, Diazepam, Bromazepam, Clobazam, Midazolam, Flurazepam & Alprazolam) & their rational use as anti-anxiety agents in the Comilla & Feni District of Bangladesh. All the prescriptions were collected in June 2015, prescribed by psychiatrists throughout May 2015. We have found prescription containing 21% Clonazepam, 12% Flurazepam, 6% Midazolam, 4% Alprazolam, 2% Bromazepam, 2% Diazepam & 2% Clobazam in Comilla district. 51% prescription did not contain any benzodiazepines. In Feni district, we have found 22% Clonazepam, 0% Flurazepam, 0% Midazolam, 11% Alprazolam, 6% Bromazepam, 0% Diazepam & 0% Clobazam in the prescription. 61% prescription in this district did not contain benzodiazepines. We found 1 prescription containing Midazolam & Flurazepam (both are benzodiazepines). In another prescription collected from Feni district, we got 1 prescription containing Clonazepam & Alprazolam. But we recommend the citation of the chief complain or diagnosis in the prescription for better understanding and justification of using any drug, especially when it is a...
Read More
Posted by admin on Nov 20, 2015 in |
Omega 3 fatty acid is one such dietary supplement, known to modulate the host response is chronic conditions like cardiovascular disease, rheumatoid arthritis, ischemic cerebrovascular disease, osteoporosis by producing resolvins and proteins without any side effects; periodontitis is an infectious disease caused predominantly by gram negative anaerobes. The effect of dietary supplementation with omega 3 fatty acid as a host modulating agent with chronic periodontitis. This review going to reveals about the omega 3 fatty acid which helps to reduce the...
Read More
Posted by admin on Aug 19, 2015 in |
A solid dispersion is the dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by melting, solvent, or melting-solvent Method. The poor solubility of drug substances in water and their low dissolution rate in the aqueous gastro-intestinal fluids often lead to insufficient bioavailability. If the dissolution rate of the active ingredient in the gastrointestinal liquid is the rate-limiting factor for the absorption of the drug, the objective of the formulation will have to be an increase in the dissolution rate. From many years, variety of solubility techniques have been used & studied for increasing solubility of poorly soluble drugs. Around 40% of chemical entities discovered by pharmaceutical industry are poorly soluble in nature. Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rate & bioavailability of the poorly soluble drugs. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This...
Read More
Posted by admin on Aug 19, 2015 in |
The marine world is largely unexplored that harbors most of the biodiversity. In recent years, marine natural products have yielded a considerable number of drug candidates. Marine microorganisms, whose genetic and biochemical diversity became a rich source of novel chemical entities for the discovery of more effective drugs. Marine microbes especially marine sponges are playing a unique contribution for human health and well- being. In addition to the primary metabolites (amino acids, nucleotides, and vitamins), they also contribute many secondary metabolites, which constitute 50% of the pharmaceuticals. Drugs derived from the marine natural products are being developed for treating cancers, immune suppressive disorders, and resistant microbial species. The need to augment production of these marine compounds to prepare various drugs through tissue culture and mariculture and their uses in human population has been stressed on this...
Read More
