Posted by admin on Feb 28, 2019 in |
Nanoemulsions have attracted great attention in research, dosage form design, and pharmacotherapy. This is as a result of some attributes peculiar to nanoemulsions such as optical clarity, ease of preparation, thermodynamic stability and increased surface area. Poor water solubility remains the main culprit for the formulation scientist which can be overcome by canonization. Nanoemulsion is a kinetically stable and isotropic system of two immiscible liquids in the submicron size range. Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Many parenteral nutrition and drug emulsions on the market confirm the safe use of NE over the years. Parenteral emulsions loaded with APIs (active pharmaceutical ingredients) are considered as drug delivery systems (DDS). DDS focuses on the regulation of the in-vivo dynamics, such as absorption, distribution, metabolism, and extended bioavailability, thereby improving the effectiveness and the safety of the drugs. Nanoemulsion is the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase using...
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Posted by admin on Feb 28, 2018 in |
Trigonella foenum-graecum, commonly known as Fenugreek, is an annual herb belonging to family Fabaceae. It is cultivated all through the world as a semiarid crop, and its seeds are rich sources of dietary protein fiber, iron B Vitamins, and several other dietary minerals. It has many potential therapeutic applications in the health sector. It contains different kinds of bioactive compounds such as diosgenin, galactomannan, 3-hydroxy-4,5-dimethyl-2(5H) furanone (stolone), 4-hydroxy isoleucene, etc. Fenugreek is one of the most ancient plants with a bunch of medicinal uses such as anti-diabetic, antipyretic, anti-inflammatory, diuretic, antiradical, antibacterial activity, etc. Fenugreek is also known to have hypocholesterolemic, digestive stimulant action, antioxidant potency, and hepatoprotective effect. Numerous experiments have been conducted to see their effectiveness to cure diseases in different ways. This review presents the major medicinal and other beneficial uses of fenugreek discovered through the last many years of research in animal and human subjects as well as in other experimental...
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Posted by admin on Feb 28, 2018 in |
The aim of the study was to determine the synergistic antimicrobial activity of a selected medicinal plant extract mixture composed of Calotropis gigantean (ElaWara, Family: Asclepiadaceae), Datura metel (Kalu Attana, Family: Solanaceae) and Ricinus communis (Erandu, Family: Euphorbiaceae) against selected gram positive and gram negative bacteria. In the study, antimicrobial activity was evaluated against two-gram positive organisms; Staphylococcus aureus (ATCC 95923) and group A Streptococcus spp. (ATCC 12384) and two gram-negative organisms; Escherichia coli (ATCC 95922) and Pseudomonas aeruginosa (ATCC 27853). Agar disc diffusion method was carried out to evaluate the antibacterial activity of the selected medicinal plant extract mixture, and the inhibition zone diameters were measured. Further, minimum inhibitory concentration (MIC) was evaluated using a broth microdilution method. The inhibition zones against S. aureus and group A Streptococcus spp. were observed. In contrast, inhibition zones were not demonstrated against selected gram-negative organisms. The MIC evaluated for S. aureus was 16 mg/mL by the broth dilution method. The results revealed that the selected medicinal plant extract mixture exerted synergistic...
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Posted by admin on Jul 12, 2017 in |
Knowing the morphology of Copper nanoparticles was confirmed by Field Emission Scanning Electron microscopy (FE-SEM). Herein, we are reporting a novel biological approach for the formation of copper nanoparticles using leave. Copper sulfate was made to reduce with an aqueous solution of Cassia auriculata leave extracts. X-Ray diffraction (XRD) pattern reveals the formation of Copper nanoparticles, which shows crystallinity. Field emission scanning electron microscopy (FE-SEM) suggested particles size and spherical shape in the range of 38.1-43.5 nm. UV absorption studies of copper nanoparticles showed that have absorbance in the range 488.5 to 514.3 nm and FT-IR studies of copper nanoparticles were showed that the stretching frequency of fingerprint region at 509.21 cm-1 for Cu-O...
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Posted by admin on Jul 12, 2017 in |
Head lice infestation or Pediculosis capitis, caused by Pediculus humanus capitis, is a common health concern. In the US, where Pediculosis capitis is the most prevalent parasitic infestation of children, 6 to 12 million people are affected every year. Pediculosis capitis remains confined to the scalp. Scalp pruritus is the cardinal symptom, although patients with lice can be asymptomatic. Pruritus with impetiginization should prompt the physician to look for lice or viable nits. All close contacts should be examined. Treatment directed at killing the lice and the ova should be considered only if active lice or viable eggs are observed. The three fundamental effective treatment options for head lice are topical pediculicides, wet combing, and oral therapy. Spraying or fogging a home with insecticides or pediculicides is not...
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