Posted by admin on May 31, 2019 in |
The purpose of the current study was to formulate nanosized bromocriptine loaded mucoadhesive bio-flexy films using biopolymer from Zea mays for improved bioavailability and therapeutic efficacy via oro-trans labio mucosal route. Bromocriptine was nanosized by a novel method using 1,2,3-propanetriol as nanosizant. The biopolymer was isolated from Zea mays by treating the aqueous extract with an optimized quantity of non-aqueous solvent. Ten nanosized drug loaded films in different ratios (1:1, 1:2,1:3, 1:4 and 1:5) of biopolymer from Zea mays and Guar gum were prepared by “Solvent Casting Technique.” Biopolymer from Zea mays and Guar gum was used as film former, 1,2,3-Propanetriol and D-glucose as flexicizer. All the films were evaluated using thickness, surface pH, folding endurance, weight and content uniformity, mucoadhesive, in-vitro drug release profile, etc. The isolated biopolymer was off-white in color, biodegradable and biocompatible. All films were thin, smooth, transparent to translucent in appearance and flexible in nature. All formulations adhered to the mucosal surface for more than 24 h. The amount of film former influenced the...
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Posted by admin on May 31, 2018 in |
The purpose of the current review is to enlighten the present and the future perspective on oral fast dissolving films (OFDFs) as a drug delivery system as they are gaining interest as a substitute of fast dissolving tablets. Tablets/capsules to modified release tablets/capsules to oral disintegrating tablet to wafer to the recent development of fast dissolving oral films. Fast dissolving drug delivery systems were first invented in the late 1970s to overcome swallowing difficulties associated with tablets and capsules for pediatric and geriatric patients. Also, solid oral delivery systems do not require sterile conditions and are therefore less expensive to manufacture, but oral drug delivery systems still need some advancements to be made because of their drawbacks related to particular class of patients which includes geriatric, pediatric and dysphagia patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking because of tablet appearance, and patients experienced...
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Posted by admin on May 31, 2018 in |
A Reverse Phase-High Performance Liquid Chromatography method has been developed and validated for the estimation of sodium benzoate and potassium sorbate in food products. The RP-HPLC method for sodium benzoate and potassium sorbate was developed using Luna C18 column (150 mm × 4.6 mm, 5 µm) as stationary phase and acetonitrile: sodium acetate buffer pH 4.3 (20:80) as mobile phase at 1.0 ml/min flow rate and detection was carried out at 235 nm and the methods were validated in accordance with ICH guidelines. Sodium benzoate and potassium sorbate have linearity in the concentration range of 1-30 µg/ml in with correlation coefficient (r2= 0.999 & r2=0.999) respectively. Sodium benzoate and potassium sorbate eluted at 4.9 and 6.9 min, respectively. The values of LOD were 0.59 and 0.39, and LOQ were 1.8 and 1.1 for sodium benzoate and potassium sorbate respectively. Results of assay and validation study are satisfactory. So, the methods can be successfully applied for the routine analysis of sodium benzoate and potassium...
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Posted by admin on Jul 12, 2017 in |
Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore a novelistic route for targeting to the brain through the ear by formulating nanosuspension using Escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardiovascular diseases. The delivery has overcome the dose dumping problem in case of the oral system. In this research work, significant effort was made to explore the novelistic platform for the ear to the brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 h. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having an r2 value of 0.9905 t 80: 22 h and best-fit model was...
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Posted by admin on Jul 12, 2017 in |
A stability-indicating High-Performance Thin-Layer Chromatographic method (HPTLC) was developed and validated as per the International Conference on Harmonization (ICH) guidelines for determination of carvedilol (CRL) both in bulk drug and solid lipid nanoparticles (SLNs). The solvent system comprised of toluene–chloroform-methanol-acetic acid (2.0:2.0:1.0:0.04, v/v/v), gave compact spot of CRL at Rf 0.56 ± 0.05. The spectrodensitometric analysis was performed at 242 nm. The linear graph upon regression analysis showed r2 = 0.998 concerning peak area at the concentration range of 50–1000 ng spot−1. The limit of detection and quantification was found to be 7.9 and 24.2 ng spot-1, respectively. The drug was subjected to stress conditions like acid and alkali hydrolysis, oxidation, photodegradation, dry as well as wet heat treatment and evaluated for stability and degradation product. The acidic and alkaline degradation kinetics was also studied using developed HPTLC method. SLNs were developed using hot melt technique and subjected stability testing along with the commercial...
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