Posted by admin on Oct 16, 2017 in |
The increasing production of cheaper and affordable generic drugs can improve the general healthcare delivery systems as well as decreasing the healthcare costs. Even though there are many generic drug brands available in the market, effective monitoring of the quality of generic drug products marketed are absent in many developing countries. This matter raises a few issues with one of it is the widespread distribution of substandard or counterfeit drug products. Substandard drug products can be defined as genuine drugs manufactured by authorized manufacturers but do not meet the quality specifications fixed for them by national standards. Also, drugs that are have three or more generic brand must be assessed and monitored to ensure its interchangeability with the innovator brand. So this study is covering the quality control tests of paracetamol tablet that are available in the local...
Read More
Posted by admin on Oct 16, 2017 in |
Diabetes mellitus is indicated by abnormal glycemic control. Blurred vision, retinopathy, dry skin, nerve damage, and kidney damage are among the common complications associated with diabetes mellitus. Diet, exercise, medications, and insulin therapy are considered better therapeutic options for diabetes mellitus. Herbal medicines have been a highly valued source of medicine throughout human history. They are widely used today, indicating that herbs are growing parts of modern high-tech medicines and some of the herbal plants and active chemical constituents have a role in the management of diabetes mellitus. In Asia, many herbs are used in everyday food, which has anti-diabetic effects directly or is effective to improve secondary complications like nephropathy, nephropathy, cardiomyopathy, etc. Allium cepa (onion), Allium sativum (garlic), Zingiber officinale (ginger), Coriandrum sativum (coriander) are the common herbs used in Asian everyday food which have been reported to alleviate diabetic conditions. The present review summarizes the benefits of these common herbs in diabetes...
Read More
Posted by admin on Sep 30, 2016 in |
Introduction: Menopause, or the permanent cessation of menstruation, is one of the significant stages in the normal development in a woman’s life. During menopause, women undergo series of endocrinal and biological changes that are associated with increased prevalence of chronic conditions such as type 2 diabetes mellitus, hypertension, osteoporosis, dyslipidemia, and obesity. Objective: Present study explores the prevalence of chronic diseases and the probable role of socioeconomic conditions in post-menopausal women in Mumbai and Karachi. Methods: A prospective cross-sectional study was done in a total of 295 post-menopausal women from Mumbai (n=150) and Karachi (n=145) to assess the prevalence of chronic diseases and their socioeconomic conditions. Results: Hypertension was the most prevalent chronic disease in post-menopausal women from Mumbai (n=28; 18.6%) as well as from Karachi (n=18; 12.4%). Type II diabetes mellitus was found to be the second most prevalent chronic disease among post-menopausal women from Mumbai (n=27; 18%) and Karachi and (n=17; 11.7%). No graduation, the income of 20,000 to 50,000 per month (Indian Rupee or Pakistan Rupee),...
Read More
Posted by admin on Aug 19, 2015 in |
Mouth dissolving tablet disintegrates within a minute without drinking water. The purpose of present work was to develop a patient-friendly tablet for antihypertensive treatment using Benazepril HCl was taste masked by complexing with indion 204 and formulate as mouth dissolving tablet (MDT). The formulated drug-resin complex was characterized by IR, DSC, etc. Overall nine mouth dissolving formulations were prepared by direct compression method using three different superdisintegrants viz. croscarmellose sodium, sodium starch glycolate, and crospovidone. The tablets disintegrated in-vitro within 20 s, and the complex drug was released from tablet within 3 min. Formulation F1 to F3 were prepared by direct compression method using sodium starch glycolate as superdisintegrants was found to release the drug in the range of 88.20 to 91.98%. Similarly, formulation F4 to F6, which were prepared by using crospovidone as superdisintegrants showed maximum percent drug release, i.e. 88.27 to 92.68%. Further, F7 to F9 were prepared by using croscarmellose sodium as superdisintegrants and showed percent drug release between 87.72 to 89.18% range. Studies indicated that...
Read More
Posted by admin on Aug 19, 2015 in |
A solid dispersion is the dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by melting, solvent, or melting-solvent Method. The poor solubility of drug substances in water and their low dissolution rate in the aqueous gastro-intestinal fluids often lead to insufficient bioavailability. If the dissolution rate of the active ingredient in the gastrointestinal liquid is the rate-limiting factor for the absorption of the drug, the objective of the formulation will have to be an increase in the dissolution rate. From many years, variety of solubility techniques have been used & studied for increasing solubility of poorly soluble drugs. Around 40% of chemical entities discovered by pharmaceutical industry are poorly soluble in nature. Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rate & bioavailability of the poorly soluble drugs. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This...
Read More
