Posted by admin on Feb 13, 2016 in |
Amylase has been exploited in textile, leather, paper, and detergent industries for washing and desizing of fabrics. It was reported to immobilize on to various compatible matrices by adopting various methods to increase its thermal and storage stability. Its immobilization onto bovine serum albumin (BSA) was observed to be very significant to synthesis its non-toxic and low-cost BSA loaded nanoparticles (BSANPs). In this designed washing study, Cicer aritenium amylase loaded butanol driven BSA nanoparticles (BSANPs) were used which were synthesized by using the desolvation method. These synthesized BSANPs were made bio-active with standardized 35U of alkaline protease for their biodegradation to allow the controlled release bound amylase. Then, this bio-active amylase loaded BSANPs were used as nano-wool shampoo additives with chosen woolen shampoo named, Perwoll Shampoo to test the stain removal efficacy from stained woolen fabric without affecting the delicacy and softness of the chosen fabric. In this study, chosen stains were comprised of daily routine stains of boot polish and hair color dye cream named, kiwi leather extra...
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Posted by admin on Jan 2, 2016 in |
Aim: The study aims to analyze the antibacterial property of various endodontic sealers against Streptococcus mutans and Enterococcus faecilis. Objective: Pulpal tissues are frequently infected by bacteria and are considered to be the commonest etiological agents of pulpal necrosis and periapical lesions, which needs endodontic treatment for its cure. Microorganisms play an important role in endodontic failures, which is commonly due to incomplete elimination of bacteria from the canal or due to the recolonization of bacteria by leakages. Thus it becomes important for the sealers to have antibacterial property. To make long-lasting restorations, the materials should be made antibacterial. The objective of this study is to check for the antibacterial property of the restorative sealers. Methodology: The antimicrobial activity of five endodontic sealers (zinc oxide eugenol, amalgam, light cure composite, calcium hydroxide, and glass ionomer) was assessed against Enterococcus faecilis and Streptococcus mutans using the agar diffusion method. Reason: Microorganisms being the commonest reason for endodontic treatment failure, endodontic sealers should possess an antimicrobial...
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Posted by admin on Dec 19, 2015 in |
A Simple, accurate, and precise high-performance thin layer chromatography method for the simultaneous estimation of ibuprofen and carisoprodol in the marketed formulation was developed. The determination was carried on silica gel 60 GF254 HPTLC plates using a mobile phase n-butanol: glacial acetic acid: Acetone (5:2:3 v/v/v). The absorbance of the spots was measured by densitometry at 254 nm. The Retention Factor (Rf) was found to be 0.87 for ibuprofen and 0.77 for carisoprodol. Ibuprofen and carisoprodol showed a linear response in the concentration range 60-180 µg/band and 35-78.75µg/band, respectively. The correlation coefficient (r2) for ibuprofen and carisoprodol was found to be 0.9992 and 0.9997, respectively. The result of the analysis has been validated statistically and by recovery studies. The percentage recoveries obtained for ibuprofen and carisoprodol ranges from 101.92 and 100.46 respectively. The proposed HPTLC method can be applied for the quantitative determination of carisoprodol and ibuprofen in bulk and drug...
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Posted by admin on Dec 17, 2015 in |
Despite the complexity of the drug use, several indicators have been developed, standardized and evaluated by WHO/world health organization, which provides useful means of measuring certain aspects of country’s drug use. These indicators are grouped into three categories, namely; prescribing indicators, patient care indicators, and facility indicators. Objective: The objective of this study was to assess patterns of drug use by using WHO prescribing and health facility indicators in Kombolcha town, Amhara region, Northern Ethiopia from May 15 to May 30/2014. Methods and Material: A cross-sectional study was carried out in selected health facilities. Equal numbers of samples were selected from the three health centers (KHC 02, 03, and 05) using a random sampling method until the desired sample size was achieved. Prescriptions were assessed according to WHO/ INRUD guideline (WHO, Policy Perspective on Medicines, 2002). Result: A total of 384 prescriptions that included 796 drugs were analyzed. 780 (98%) drugs were prescribed using generic names. The average number of drugs per prescription was 2.1. In 241 (30.2%) of...
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Posted by admin on Dec 13, 2015 in |
Background: Recently, in the discipline of ophthalmology, there have been many developments and introduction of new ocular therapeutic agents. To improve drugs therapeutic efficacy, minimize adverse effects, and delay development of resistance drug utilization trends and patients need to be evaluated periodically. Objective: To assess the prescribing, drug use, and to dispense practice of ophthalmic drugs at Boru hospital. Methodology: Cross-sectional study was conducted on patients attending outpatient department pharmacy of Boru Meda hospital to collect their medicines. Prescriptions of 84 patients encountered were analyzed using World Health Organization (WHO) prescribing indicators and additional indices. Result: Analysis showed that the mean number of drug per prescription was 2.2 and 97.2% of prescribed drugs were from the national essential drug list. 89.5% of drugs were prescribed by their generic name. Majority of the prescribed drugs were antibiotics (62.7%), and only 17.7% of the prescriptions had a frequency of dosing. Percentage of patients with good post-dispensing knowledge on the dispensed ophthalmic drugs was 37.1%. Dispensing and counseling time were 18sec and...
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