Posted by admin on May 2, 2015 in |
In this study, an attempt was made to design and evaluate oral sustained release matrix tablets of ciprofloxacin using methocel K4M CR, HPMC 15 cps, avicel PH 101 as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability, and drug content. All the formulations showed compliance with pharmacopeial standards. In vitro release studies were performed using USP type II apparatus (paddle method) in 900 ml of 0.1N HCl at 50 rpm for 8 h. The release kinetics was analyzed using the zero-order, first order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations to explore and explain the mechanism of drug release from the matrix tablets. In vitro release studies revealed that percent drug release decreased with increase of polymer loading. Based on the dissolution data comparison with innovator brand F-5 formulation (16% Methocel K4M CR w/w of drug) was elected as the best formulation. The drug release profile of the best formulation was well controlled and uniform throughout the...
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Posted by admin on Apr 29, 2015 in |
Diabetic nephropathy is the leading cause of chronic kidney disease in patients starting renal replacement therapy. Dialysis is the artificial process of getting rid of waste (diffusion) and unwanted water (ultrafiltration) from the blood. This process is naturally done by our kidneys. Dialysis may be used for people who have become ill and have acute kidney failure (temporary loss of kidney function), or for fairly stable patients who have permanently lost kidney function. In dialysis patients, parameters like glucose, creatinine, total protein concentration, triglycerides, and albumin levels are frequently changed before and after the dialysis. The mean values of glucose have far related to the values taken after the dialysis. The mean values are 144.544, 89.082, and 1.545, 1.465 for glucose and creatinine before and after the...
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Posted by admin on Apr 29, 2015 in |
Herbal drugs constitute a major part in all the traditional systems of medicine. From the literature review, it comes to know that Acacia arabica stem is used as a chewing stick and claimed to be useful for bleeding gums and pain related to it. In some communities use of leaves is also known. The components are taken from live parts as they are, without allowing them to dry for a long period, which may lead to enzymatic degradation over the process of drying. The juice is dried at room temperature to avoid degradation of heat sensitive moiety if any, that may be present in the juice. This dried juice is expected to have properties which will be useful for the treatment of inflammation. The properties analyzed here are the anti-inflammatory activity of stem and leaf juice. The objective of the proposed study is to perform the phytochemical studies on the fresh juice of babul stem and leaves. It is further envisaged to study anti-inflammatory properties of the dried fresh...
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Posted by admin on Apr 14, 2015 in |
Mucilages of plant origin have been used widely as demulcent because of their unique properties to bind with the mucous membrane. Isolation of water-soluble components from the natural edible sources was carried out by cold/hot aqueous extraction process followed by the organic solvent precipitation. The yield of Pithecellobium dulce (PD), Prosopis juliflora (PJ), Acacia arabica (AA) and Abelmoschus esculanthus (AE) was ≈5.49, 4.91, 3.46, 3.87 % w/w respectively to the initial weight. The isolated mucoadhesive materials obtained from natural sources were proved to be safe and free from toxic or adverse effects. Swollen volumes after 24 h of hydration were found to be 12.1, 12.4, 13.3, and 18.3 indicating their moderate swellability compared to 27.4 of carbopol 934 P (CP), 25.7 of sodium alginate (SAA), 1.2 of guar gum (GG) and 6.4 of hydroxy propyl methyl cellulose (HPMC). The moisture sorption capacities of PD & PJ are very less. The loss on drying of PD, PJ, and AA & AE was less than the official limit of 6%. The...
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Posted by admin on Apr 14, 2015 in |
Diabetes mellitus is one of the most critical health conditions around the world, not only in terms of the number of affected people, disability, and premature mortality but also in regards to the health care costs involved in controlling and treating its complications. Among the most constant ailments, the diabetic patient suffers is the diabetic foot, defined as any infection, ulceration, and necrosis of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular disease of the lower limbs. This study determines the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers. A record based study was conducted among 169 diabetic foot ulcer patients admitted in the hospital; Details regarding the Culture and antibiotic susceptibility of specimens (pus samples from foot ulcers) from these 104 patients were collected. Commonest microorganisms isolated in this study were Pseudomonas, Staphylococcus, Klebsiella, Proteus, and E. coli. Gram-positive organisms were highly sensitive to Vancomycin, Linezolide, and gram-negative were sensitive to Amikacin and...
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