Posted by admin on Jun 30, 2015 in |
Aim And Objective: This review aims to find the sialic acid level in oral cancer patients. Background: Oral cavity cancer is currently the most frequent cause of cancer-related death among Indian men. It is preceded by oral precancerous conditions like leukoplakia or oral sub mucous fibrosis. Altered cell surface topography is the soul of the malignant cell. Early detection is the key to treat oral cancer. Attempts are on to develop sensitive, specific, and reliable biochemical tests for early detection and diagnosis. Glycoproteins and Glycolipids are important constituents of the cell membrane; hence, they play an important role in malignancy. Glycoconjugates are released into the circulation in increased level from malignant cells due to increased turnover, secretion, or shedding of malignant cells. So the measurement of and salivary glycoprotein and glycolipids has received a wide range of acceptance in the screening of oral cancer. Sialic acid is N-acetyl neuraminic acid. It is a negatively charged nine-carbon monosaccharide commonly attached to carbohydrate chains of glycoproteins and glycolipids. Salivary glycoproteins play...
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Posted by admin on Jun 13, 2015 in |
Fluoroquinolones are synthetic fluorinated derivatives of nalidixic acid and are an important group of antibacterials along with the beta-lactam and macrolides are used for the treatment of various infectious diseases in adults; however, their use in children has been limited as the result of fluoroquinolone-induced musculoskeletal toxicity in animal studies. Those antibiotics are useful in the treatment of cystic fibrosis, urinary tract infections, neutropenia, gastrointestinal infections, meningitis with resistant bacteria, chronic suppurative otitis media, some cases of complicated acute otitis media, conjunctivitis, infections caused by Enterobacteriaceae (including the neonatal period), some mycobacterial infections, prophylaxis of anthrax and sepsis caused by other antibiotic-resistant organisms in pediatrics. Most of the available human studies showed the incidence of a musculoskeletal adverse event is relatively higher in fluoroquinolones than nonfluoroquinolone antibiotics; however, almost all AEs are reversible and transient. Hence, fluoroquinolones can be clinically considered in children when the benefit outweighs the possible...
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Posted by admin on Jun 13, 2015 in |
Background: The use of long-acting and permanent contraceptive methods (LAPMs) has not kept step with that of short-acting methods such as oral pills and injectables in Africa. Ethiopia is the second most populous country in sub-Saharan Africa with a high total fertility rate and high maternal and child mortality rates. Therefore, this study summarized the evidence of practice and intention to use long-acting and permanent family planning methods among women in Ethiopia using systemic review and meta-analysis. Methods and findings: Systematic review of the published literature of observational studies was conducted. Original studies were identified using databases of Medline/Pubmed and Google Scholar. Heterogeneity across studies was checked using the Cochrane Q test statistic and I2. Pool risk estimates of intention to use and practice of long-acting and permanent family planning methods were computed using a random effect model. Based on the nine observational studies included in the meta-analysis, the pooled prevalence of intention to use long-acting and permanent family planning methods among married women according to random effect DL...
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Posted by admin on Jun 13, 2015 in |
Pain is a subjective, multidimensional and unpleasant experience allied with actual or potential tissue damage comprising sensory, affective and cognitive components. Pain signals interpretation is a complex process that entails excitation of peripheral nerves and further excitation of nociceptive inputs. Painkiller is member of diverse group of drugs used to relieve pain and to achieve analgesia. Fever is recognized as physiological response which is triggered by infectious stimuli or aseptic stimuli. Elevation in body temperature occur when concentrations of prostaglandin-E2 (PGE2) increases within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. It is commonly suppressed with antipyretic medications. Several traditional medicinal systems are available for the treatment of pain & fever like ayurveda, unani, chinese, homeopathic, physiotherapy & non- pharmacological procedures etc. Pain & fever treatment in allopathic system are frequently used but has many adverse effects like renal & liver dysfunction, ulceration, sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance and respiratory depression etc. This compilation addresses...
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Posted by admin on May 2, 2015 in |
Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid- dosage forms. Fast dissolving films have become a novel approach to oral drug delivery system as it provides convenience and ease of use over other dosage forms such as orally disintegrating tablets, buccal tablets, and sublingual tablets, so mouth dissolving films are gaining the interest of a large number of pharmaceutical industries. Mouth dissolving films are thin solid dosage forms which, when placed in the oral cavity, dissolve within a few seconds without chewing and intake of water. The oral, buccal mucosa being highly vascularized, drugs can absorb directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism. This advantage can be exploited in preparing products with improved oral bioavailability of molecules that undergo first pass effect. These films offer a convenient way of dosing medication pediatric, geriatric, and bedridden patients. The sublingual and buccal delivery of...
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