Posted by admin on Mar 31, 2018 in |
The advancements of cancer research if put in a nutshell can be described as: “Cancer is a genetic disease.” From the past two decades, several actors for cancer are identified, their mutations are characterized, and the pathways they control are described. Intricate relations among JAK-STAT, TGF-B, MAPK, Ras, Wnt, Notch, and Hedgehog signaling pathway have a vital role in apoptosis, survival, proliferation, and differentiation. Dysregulation of these pathways due to driver mutations are often found involved in the growth of cancer. The purpose of this review is to enlighten the advancement in these areas of cancer, specify where there is room for research, and provide a potential base for future...
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Posted by admin on Feb 28, 2018 in |
Trigonella foenum-graecum, commonly known as Fenugreek, is an annual herb belonging to family Fabaceae. It is cultivated all through the world as a semiarid crop, and its seeds are rich sources of dietary protein fiber, iron B Vitamins, and several other dietary minerals. It has many potential therapeutic applications in the health sector. It contains different kinds of bioactive compounds such as diosgenin, galactomannan, 3-hydroxy-4,5-dimethyl-2(5H) furanone (stolone), 4-hydroxy isoleucene, etc. Fenugreek is one of the most ancient plants with a bunch of medicinal uses such as anti-diabetic, antipyretic, anti-inflammatory, diuretic, antiradical, antibacterial activity, etc. Fenugreek is also known to have hypocholesterolemic, digestive stimulant action, antioxidant potency, and hepatoprotective effect. Numerous experiments have been conducted to see their effectiveness to cure diseases in different ways. This review presents the major medicinal and other beneficial uses of fenugreek discovered through the last many years of research in animal and human subjects as well as in other experimental...
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Posted by admin on Jan 15, 2018 in |
Lagerstroemia speciosa, commonly known as jarul, is one of those precious medicinal herbs of Lythraceae that are still included in un-utilized herbs in spite of the variety of useful pharmacological properties it possesses. Extracts of Lagerstroemia speciosa have anti-diabetic, hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, xanthine-oxidase inhibitors, antibacterial, antiviral, cytotoxic, anti-fibrotic, antinociceptive, antidiarrhoeal and other activities. Here, we have reviewed all the reported phytochemistry and pharmacological properties of the plant and its...
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Posted by admin on Jan 13, 2018 in |
Helminthiasis is prevalent globally, but is more common in developing countries with poorer personal and environmental hygiene. In the human body gastrointestinal tract is the abode of many helminths, but some also live in tissue. They harm the host by depriving him of food, causing blood loss, injury to organs, intestinal or lymphatic obstruction. It is estimated that hundreds of millions of people harbor parasitic worms and one-third of the almost three billion people that live below the poverty line in developing regions of sub-Saharan Africa, Asia, and the Americas are infected with one or more helminth. This review gives an overview of symptoms, diagnosis, treatment, prevalence, and herbs used in...
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Posted by admin on Jan 13, 2018 in |
The relentlessly beating heart has the greatest oxygen consumption of any organ in the body at rest, reflecting its huge metabolic turnover and energetic demands. The vast majority of its energy is produced and cycled in the form of ATP which stems mainly from oxidative phosphorylation occurring at the respiratory chain in the mitochondria. A part of energy production, the respiratory chain is also the main source of reactive oxygen species and plays a pivotal role in the regulation of oxidative stress. Dysfunction of the respiratory chain is therefore found in most common heart conditions. The pathophysiology of mitochondrial respiratory chain dysfunction in hereditary cardiac mitochondrial disease, the aging heart, in LV hypertrophy and heart failure, and ischemia-reperfusion injury is reviewed. We introduce the practicing clinician to the complex physiology of the respiratory chain, highlight its impact on common cardiac disorders, and review translational pharmacological and non-pharmacological treatment...
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