Posted by admin on Apr 24, 2016 in |
Infection is the major problems in a diabetic patient where the healing process are slow down and increases complications. Antiseptics helps to limit the growth of unwanted bacteria (opportunistic pathogen) superficially but do not work in case of deeper infection as its mode of action slows down after some time. The use of antibiotics also emerges multi-drug resistant pathogens, which are considered more dangerous and difficult to treat. Therefore, a new approach to wound therapy is expected that can escape many of the problems associated with current antibiotic treatments. In this regards, genetically engineered bacteria and their products may enhance the natural wound healing process. Wound healing factors like growth factors as well as fibroblast can be incorporated into bacteria genome which will promote healing mechanism speedily. In this aspect, modified bacteria will also prevent the unnecessary growth of the opportunistic pathogen. Many advantages are anticipated from the use of genetically modified organism and its products in wound treatment. The present review is focussed on the various approach of...
Read More
Posted by admin on Mar 13, 2016 in |
Lurasidone is an atypical antipsychotic approved by the FDA for the treatment of schizophrenic disorder and depressive episodes linked through bipolar I disorder in adults when used exclusively or in combination with lithium or valproate. Lurasidone is a benzisothiazole antipsychotic, an antagonist at D2, 5-HT2A and 5-HT7 receptors and a partial agonist at 5-HT1A receptors. As with other antipsychotics, the exact mechanism of action of lurasidone is unknown, although its effects in schizophrenia are supposed to be related to D2 and 5-HT2A receptor antagonism. This work includes published analytical methods so far reported in the literature, for estimation of lurasidone in biological samples and pharmaceutical formulations. Techniques like UV – Visible Spectrophotometry, high – performance liquid – chromatography (HPLC), high – performance thin – layer chromatography (HPTLC), and Liquid chromatography-mass spectroscopy (LC-MS) with ESI has been used for analysis, from which it can be witnessed that high-performance liquid chromatography methods have been applied most...
Read More
Posted by admin on Feb 13, 2016 in |
Ficus religiosa Linn. is a large evergreen tree found throughout India, wild as well as cultivated, it is widely branched tree with leathery, heart-shaped, long tipped leaves. It is a sacred plant in India. It is one of the most versatile plants having a wide variety of medicinal activities, therefore, used in the treatment of several types of diseases, e.g., diarrhea, diabetes, urinary disorders, burns, hemorrhoids, gastrohelcosis, skin diseases, convulsions, tuberculosis, fever, paralysis, oxidative stress, bacterial infections, etc. This is a unique source of various types of compounds having diverse chemical structure (phenolics, sterols etc.). In this article, we will review the knowledge regarding...
Read More
Posted by admin on Jan 2, 2016 in |
Cardamom is a seed pod, known since antiquity for its culinary and medicinal properties. The spice is native to the evergreen rain forest of southern India and now grown in only a few tropical countries. Cardamom has also been found to regulate inflammatory and immune activities and may be useful for cancer prevention. Cardamom extracts are effective against oral pathogenic bacteria like Streptococcus mutans and Candida albicans. Most people use cardamom as a spice and are largely unaware of its numerous health benefits. This article briefs the various health benefits of...
Read More
Posted by admin on Dec 19, 2015 in |
Poor solubility remains one of the more challenging and critical tasks in drug discovery and development, and it is also the main cause of low bioavailability and poor therapeutic efficacy of the drug. Many solubility enhancement techniques are available in literature like cyclodextrin inclusion complexes, salt formation, solid dispersion, drug delivery carrier approach and prodrug approach are useful, but the most widely used technique for enhancing the solubility of poorly soluble drugs is by encapsulating the drug is lipid-based excipients, which enhances solubilization of the drug in excipient matrix, lead to enhanced bioavailability and improved therapeutic efficacy. Many lipid-based drug delivery systems are available like self-emulsifying drug delivery system (SEDDS), liposomes, solid lipid nanoparticles, nanostructured lipid carrier, which are widely used for lipophilic drugs. In this review, we highlighted some novel mechanisms for drug absorption through lipid-based systems and its commercial applications in the pharmaceutical and biological...
Read More
