Posted by admin on Jan 29, 2017 in |
Transdermal drug delivery system was first introduced more than 30 years ago. The technology generated tremendous excitement and interest amongst major pharmaceutical companies in the 1980s and 90s. By the mid to late 1990s, the trend of transdermal drug delivery system merged into larger organizations. Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes; hence, these can be used widely in place of liposomes. Ethosomes have become an area of research interest because of its enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency, etc. The purpose of writing this review on ethosomes drug delivery was to compile the focus on the various aspects of ethosomes including their mechanism of penetration, preparation, advantages, composition, characterization, application and ethosomes. Characterizations of ethosomes include particle size, zeta potential, Differential Scanning Calorimetry, entrapment efficiency, surface tension activity...
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Posted by admin on Feb 13, 2016 in |
Amylase has been exploited in textile, leather, paper, and detergent industries for washing and desizing of fabrics. It was reported to immobilize on to various compatible matrices by adopting various methods to increase its thermal and storage stability. Its immobilization onto bovine serum albumin (BSA) was observed to be very significant to synthesis its non-toxic and low-cost BSA loaded nanoparticles (BSANPs). In this designed washing study, Cicer aritenium amylase loaded butanol driven BSA nanoparticles (BSANPs) were used which were synthesized by using the desolvation method. These synthesized BSANPs were made bio-active with standardized 35U of alkaline protease for their biodegradation to allow the controlled release bound amylase. Then, this bio-active amylase loaded BSANPs were used as nano-wool shampoo additives with chosen woolen shampoo named, Perwoll Shampoo to test the stain removal efficacy from stained woolen fabric without affecting the delicacy and softness of the chosen fabric. In this study, chosen stains were comprised of daily routine stains of boot polish and hair color dye cream named, kiwi leather extra...
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Posted by admin on Feb 13, 2016 in |
Ficus religiosa Linn. is a large evergreen tree found throughout India, wild as well as cultivated, it is widely branched tree with leathery, heart-shaped, long tipped leaves. It is a sacred plant in India. It is one of the most versatile plants having a wide variety of medicinal activities, therefore, used in the treatment of several types of diseases, e.g., diarrhea, diabetes, urinary disorders, burns, hemorrhoids, gastrohelcosis, skin diseases, convulsions, tuberculosis, fever, paralysis, oxidative stress, bacterial infections, etc. This is a unique source of various types of compounds having diverse chemical structure (phenolics, sterols etc.). In this article, we will review the knowledge regarding...
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Posted by admin on Feb 2, 2015 in |
Background: Forced degradation studies are used to determine the degradation pathways and degradation products of the active pharmaceutical ingredients that could form during storage and facilitate formulation development, manufacturing and packaging. Aim: To develop and validate simple and precise stability indicating UV Spectrophotometric method for Metformin Hydrochloride in the bulk and tablet dosage form. Material and Method: Separation of the drug from its degradation products was achieved by UV Spectrophotometric method using distilled water and scanned between 200 to 400 nm. Metformin Hydrochloride was subjected to stress conditions such as hydrolysis (acid and base), oxidation, photolysis, and thermal degradation. The degraded samples were further analyzed by using this method. Results: The maximum absorbance was found to be at 232.2nm and found to be linear over the range 2-10µg/ml with good correlation coefficient (r2) 0.998. The limits of detection and quantification were 0.5232 and 1.5856µg/ml, respectively. Major degradation was observed in acid hydrolysis, photolysis, and oxidative conditions. Metformin Hydrochloride was quite stable under the other stress conditions investigated. Conclusion: The...
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Posted by admin on Feb 2, 2015 in |
In-vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a convenient, cost-effective, and predictive means of characterizing the toxic potential of new chemical entities. The early and routine implementation of this testing is a testament to its prognostic importance for humans. Anticancer activity of different concentrations (20-100) of plant extracts Terminalia arjuna was shown against Hep3-B. MTT [(3, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide)] assay was done in-vitro cytotoxicity test. The low concentration does not show the activities were as extract with 80 μl, and 100 μl concentration showed the activity against Human hepatoma cell...
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