Posted by admin on Mar 13, 2016 in |
The drug discovery and computational advances have helped chemists to develop drugs having utility for specific functional applications along with nutritional aspects. This enables researchers to design formulations and synthesized proper medicines as nutrients. Preparation of nutraceutical formulation that to a veterinary formulation is one of the challenging tasks. Various types of formulations have been devised for sustainable release, easier dissolution with no side effects, and target specific delivery of the chosen drug. The oral administration of veterinary drugs is one of the difficult task, particularly the formulation with the disagreeable smell, taste as well as low nutritional value. Considering these, it was planned to develop easy and likable preparation of nutraceutical formulation of the veterinary drug for easy oral delivery, comprising sustain release of the drug. In the present report, discussion of the formulation of ketoprofen in which veterinary drug is incorporated along with the groundnut or cottonseed oil cake through adsorption method of formulation preparation. Such a formulation can be assimilated effectively by ruminants as the oil...
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Posted by admin on Mar 13, 2016 in |
Background: Medication non-adherence is a growing burden to the health care system in Malaysia. Aim: The study aimed to determine the prevalence, severity, outcome, and factors associated with emergency department (ED) visit due to medication non-adherence at a teaching hospital in Malaysia. Methods: A cross-sectional study design was conducted on patients at the ED of Hospital Universiti Sains Malaysia over six weeks from December 2014 to January 2015. Data were collected using patient interview and review of patient’s medical records. Statistical analysis: Descriptive statistics and multiple logistic regression. Results: Out of the 434 patients on ED visit, 63 (14.5%) [95%CI, 11.0%, 18.0%] were related to medication non-adherence, out of which, 53 (84.1%) experienced severe outcome of the ED visit, 48 (76.2%) were admitted to the ED observation ward, 10 (15.9%) to the hospital ward and 5 (7.9%) were discharged immediately after they have consulted with the ED-physician. Factors associated with the ED visit due to medication non-adherence were: cardiovascular disorder [OR: 7.5 (95%CI 5.3, 11.0)], tuberculosis [OR: 5.5 (95%...
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Posted by admin on Mar 13, 2016 in |
Lurasidone is an atypical antipsychotic approved by the FDA for the treatment of schizophrenic disorder and depressive episodes linked through bipolar I disorder in adults when used exclusively or in combination with lithium or valproate. Lurasidone is a benzisothiazole antipsychotic, an antagonist at D2, 5-HT2A and 5-HT7 receptors and a partial agonist at 5-HT1A receptors. As with other antipsychotics, the exact mechanism of action of lurasidone is unknown, although its effects in schizophrenia are supposed to be related to D2 and 5-HT2A receptor antagonism. This work includes published analytical methods so far reported in the literature, for estimation of lurasidone in biological samples and pharmaceutical formulations. Techniques like UV – Visible Spectrophotometry, high – performance liquid – chromatography (HPLC), high – performance thin – layer chromatography (HPTLC), and Liquid chromatography-mass spectroscopy (LC-MS) with ESI has been used for analysis, from which it can be witnessed that high-performance liquid chromatography methods have been applied most...
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Posted by admin on Apr 14, 2015 in |
Mucilages of plant origin have been used widely as demulcent because of their unique properties to bind with the mucous membrane. Isolation of water-soluble components from the natural edible sources was carried out by cold/hot aqueous extraction process followed by the organic solvent precipitation. The yield of Pithecellobium dulce (PD), Prosopis juliflora (PJ), Acacia arabica (AA) and Abelmoschus esculanthus (AE) was ≈5.49, 4.91, 3.46, 3.87 % w/w respectively to the initial weight. The isolated mucoadhesive materials obtained from natural sources were proved to be safe and free from toxic or adverse effects. Swollen volumes after 24 h of hydration were found to be 12.1, 12.4, 13.3, and 18.3 indicating their moderate swellability compared to 27.4 of carbopol 934 P (CP), 25.7 of sodium alginate (SAA), 1.2 of guar gum (GG) and 6.4 of hydroxy propyl methyl cellulose (HPMC). The moisture sorption capacities of PD & PJ are very less. The loss on drying of PD, PJ, and AA & AE was less than the official limit of 6%. The...
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Posted by admin on Apr 14, 2015 in |
Diabetes mellitus is one of the most critical health conditions around the world, not only in terms of the number of affected people, disability, and premature mortality but also in regards to the health care costs involved in controlling and treating its complications. Among the most constant ailments, the diabetic patient suffers is the diabetic foot, defined as any infection, ulceration, and necrosis of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular disease of the lower limbs. This study determines the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers. A record based study was conducted among 169 diabetic foot ulcer patients admitted in the hospital; Details regarding the Culture and antibiotic susceptibility of specimens (pus samples from foot ulcers) from these 104 patients were collected. Commonest microorganisms isolated in this study were Pseudomonas, Staphylococcus, Klebsiella, Proteus, and E. coli. Gram-positive organisms were highly sensitive to Vancomycin, Linezolide, and gram-negative were sensitive to Amikacin and...
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