Posted by admin on Apr 14, 2015 in |
Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. The present research work was an attempt to formulate and evaluate paliperidone delayed-release tablets. A combination of hydroxypropyl methylcellulose (HPMC K100M) and polyvinyl acetate phthalate, cellulose acetate phthalate were used as polymers. The tablets were prepared by direct compression method. 12 formulations were prepared by changing the ratios of the drug and polymer to study the effect of variable concentrations of polymers and characteristics of the tablets. The prepared tablets were evaluated by different parameters such as Thickness, weight variation, hardness, content uniformity. The tablets were also evaluated for in vitro drug release in 0.1N HCl for 12 h in USP Type II dissolution apparatus. Among all the formulations (F-I to F-XII) prepared, batch F-12 gave good results of Paliperidone when compared to other formulations. Hence, formulation F12 was found to be equivalent to a marketed product with good bioavailability properties. It also showed no significant change in physical appearance and drug...
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Posted by admin on Apr 14, 2015 in |
Sumatriptan is a potent and selective 5-hydroxytryptamine agonist. It is an effective agent in the treatment of acute migraine attack. Sumatriptan is rapidly but incompletely absorbed following oral administration and undergoes first-pass metabolism resulting in a low absolute bioavailability of 15%. The biological half-life of Sumatriptan is about 2.5 h. The aim was to develop gastro-retentive floating microbeads which improve the absolute bioavailability of Sumatriptan by avoiding the presystemic metabolism and thereby to reduce the dose frequency. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to FTIR spectrophotometry, capability of floating in the gastric condition was evaluated. The beads were prepared by Ionotropic gelation method. By using Sodium alginate, hydroxyl propyl methylcellulose K4M and guar gum grade in 1:1, 1:2, 1:3 ratios. The beads were evaluated for percent drug entrapment efficiency, and in-vitro drug release. The in-vitro drug release study of the beads was carried out in simulated gastric media by USP dissolution method. Beads formulated employing Sodium alginate alone could not sustain...
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Posted by admin on Apr 14, 2015 in |
The RFID (Radio Frequency Identification) is a decade old wireless technology based on radio frequencies and is a member of Automatic Identification and Data Capture (AIDC) family. Its first application was seen around in the year 1945, and in recent years numerous applications have been evolved and are practically implemented in approximately every field. The motive of this work is to survey the different applications in the present scenario in the field of...
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