Posted by admin on May 2, 2015 in |
In this study, an attempt was made to design and evaluate oral sustained release matrix tablets of ciprofloxacin using methocel K4M CR, HPMC 15 cps, avicel PH 101 as the retardant polymer. Tablets were prepared by conventional wet granulation technique. Tablets were evaluated for parameters such as weight variation, hardness, friability, and drug content. All the formulations showed compliance with pharmacopeial standards. In vitro release studies were performed using USP type II apparatus (paddle method) in 900 ml of 0.1N HCl at 50 rpm for 8 h. The release kinetics was analyzed using the zero-order, first order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations to explore and explain the mechanism of drug release from the matrix tablets. In vitro release studies revealed that percent drug release decreased with increase of polymer loading. Based on the dissolution data comparison with innovator brand F-5 formulation (16% Methocel K4M CR w/w of drug) was elected as the best formulation. The drug release profile of the best formulation was well controlled and uniform throughout the...
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Posted by admin on May 2, 2015 in |
Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid- dosage forms. Fast dissolving films have become a novel approach to oral drug delivery system as it provides convenience and ease of use over other dosage forms such as orally disintegrating tablets, buccal tablets, and sublingual tablets, so mouth dissolving films are gaining the interest of a large number of pharmaceutical industries. Mouth dissolving films are thin solid dosage forms which, when placed in the oral cavity, dissolve within a few seconds without chewing and intake of water. The oral, buccal mucosa being highly vascularized, drugs can absorb directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism. This advantage can be exploited in preparing products with improved oral bioavailability of molecules that undergo first pass effect. These films offer a convenient way of dosing medication pediatric, geriatric, and bedridden patients. The sublingual and buccal delivery of...
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Posted by admin on May 2, 2015 in |
According to the research by the World Health Organisation (WHO), 36 million people die each year due to various health problems. However, this number can be reduced if patients are detected early and treated properly. The expansion and use of electronic nose have many applications in the healthcare, and a bio-medical field is rapid to accelerate over the past 25 years. Many e-nose technologies have given answers or provided results of complex biomedical and healthcare problems. The purpose of this review is to present the use of e-nose in the medical field, or how e-nose helps in detecting various diseases in human at an early stage so that it can be cured easily. E-nose is a device which is being developed as systems for the detection of miscellaneous odors. These odors can be of food, drinks, cosmetics, medicines, etc. With the help of an array of sensors placed inside it, detection is possible. Various diseases like lung cancer, asthma in children, diagnosis of illness by breathing analysis, prostate cancer,...
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Posted by admin on May 2, 2015 in |
Improving oral bioavailability of drugs those used as solid dosage forms remains a challenge for the formulation scientists due to solubility problems associated with it. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Solid dispersion techniques have attracted the considerable interest in improving the dissolution rate of highly lipophilic drugs, thereby improving their bioavailability by micronization, improving wettability and use of a surface active agent. The term solid dispersion refers to a cluster of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. This article reviews the historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This review also discusses the recent advances in the field of solid dispersion technology. The experience with solid dispersions over the last 10-15 years indicates that this is a very fruitful approach in improving the release rate and oral...
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