Posted by admin on Jan 2, 2016 in |
Aim: The study aims to analyze the antibacterial property of various endodontic sealers against Streptococcus mutans and Enterococcus faecilis. Objective: Pulpal tissues are frequently infected by bacteria and are considered to be the commonest etiological agents of pulpal necrosis and periapical lesions, which needs endodontic treatment for its cure. Microorganisms play an important role in endodontic failures, which is commonly due to incomplete elimination of bacteria from the canal or due to the recolonization of bacteria by leakages. Thus it becomes important for the sealers to have antibacterial property. To make long-lasting restorations, the materials should be made antibacterial. The objective of this study is to check for the antibacterial property of the restorative sealers. Methodology: The antimicrobial activity of five endodontic sealers (zinc oxide eugenol, amalgam, light cure composite, calcium hydroxide, and glass ionomer) was assessed against Enterococcus faecilis and Streptococcus mutans using the agar diffusion method. Reason: Microorganisms being the commonest reason for endodontic treatment failure, endodontic sealers should possess an antimicrobial...
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Posted by admin on Jan 2, 2016 in |
Cardamom is a seed pod, known since antiquity for its culinary and medicinal properties. The spice is native to the evergreen rain forest of southern India and now grown in only a few tropical countries. Cardamom has also been found to regulate inflammatory and immune activities and may be useful for cancer prevention. Cardamom extracts are effective against oral pathogenic bacteria like Streptococcus mutans and Candida albicans. Most people use cardamom as a spice and are largely unaware of its numerous health benefits. This article briefs the various health benefits of...
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Posted by admin on Dec 19, 2015 in |
A Simple, accurate, and precise high-performance thin layer chromatography method for the simultaneous estimation of ibuprofen and carisoprodol in the marketed formulation was developed. The determination was carried on silica gel 60 GF254 HPTLC plates using a mobile phase n-butanol: glacial acetic acid: Acetone (5:2:3 v/v/v). The absorbance of the spots was measured by densitometry at 254 nm. The Retention Factor (Rf) was found to be 0.87 for ibuprofen and 0.77 for carisoprodol. Ibuprofen and carisoprodol showed a linear response in the concentration range 60-180 µg/band and 35-78.75µg/band, respectively. The correlation coefficient (r2) for ibuprofen and carisoprodol was found to be 0.9992 and 0.9997, respectively. The result of the analysis has been validated statistically and by recovery studies. The percentage recoveries obtained for ibuprofen and carisoprodol ranges from 101.92 and 100.46 respectively. The proposed HPTLC method can be applied for the quantitative determination of carisoprodol and ibuprofen in bulk and drug...
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Posted by admin on Dec 19, 2015 in |
Poor solubility remains one of the more challenging and critical tasks in drug discovery and development, and it is also the main cause of low bioavailability and poor therapeutic efficacy of the drug. Many solubility enhancement techniques are available in literature like cyclodextrin inclusion complexes, salt formation, solid dispersion, drug delivery carrier approach and prodrug approach are useful, but the most widely used technique for enhancing the solubility of poorly soluble drugs is by encapsulating the drug is lipid-based excipients, which enhances solubilization of the drug in excipient matrix, lead to enhanced bioavailability and improved therapeutic efficacy. Many lipid-based drug delivery systems are available like self-emulsifying drug delivery system (SEDDS), liposomes, solid lipid nanoparticles, nanostructured lipid carrier, which are widely used for lipophilic drugs. In this review, we highlighted some novel mechanisms for drug absorption through lipid-based systems and its commercial applications in the pharmaceutical and biological...
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Posted by admin on Dec 17, 2015 in |
Despite the complexity of the drug use, several indicators have been developed, standardized and evaluated by WHO/world health organization, which provides useful means of measuring certain aspects of country’s drug use. These indicators are grouped into three categories, namely; prescribing indicators, patient care indicators, and facility indicators. Objective: The objective of this study was to assess patterns of drug use by using WHO prescribing and health facility indicators in Kombolcha town, Amhara region, Northern Ethiopia from May 15 to May 30/2014. Methods and Material: A cross-sectional study was carried out in selected health facilities. Equal numbers of samples were selected from the three health centers (KHC 02, 03, and 05) using a random sampling method until the desired sample size was achieved. Prescriptions were assessed according to WHO/ INRUD guideline (WHO, Policy Perspective on Medicines, 2002). Result: A total of 384 prescriptions that included 796 drugs were analyzed. 780 (98%) drugs were prescribed using generic names. The average number of drugs per prescription was 2.1. In 241 (30.2%) of...
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