Posted by admin on Jul 20, 2015 in |
A prospective observational study was conducted to assess the prescribing pattern of ceftriaxone and to determine the indication for which ceftriaxone prescribed in a general medicine department of a south Indian teaching hospital. A total of 200 prescriptions were collected, collated, and analyzed from the general medicine department for 6 months. Out of 200 study population included in the study, the majority are males. The frequent condition for hospitalization and for which the ceftriaxone was prescribed was respiratory tract infection. The defined daily dosage was proper for 182 patients, and average DDD of ceftriaxone was 2.06. The average total cost incurred for Ceftriaxone per patient was found to be Rs.654.64, for an average of 2.32 days. The prescriber should follow the standard treatment guidelines for improving rational use and to prevent the development of resistance. The specificity of the prescribing pattern of ceftriaxone was more; it means specific therapy was more than empirical therapy. The hospital was largely in compliances with WHO DDDs. The duration of use of ceftriaxone...
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Posted by admin on Jul 20, 2015 in |
Dermatologists should be aware of cosmeceutical products and have access to accurate scientific theory with validated data-if any exists-to support cosmeceutical claims. The question remains whether it is possible to deliver adequate doses to the skin in-vivo and to produce clinical or histological effects. It is important to evaluate these new products with a critical and careful methodology, considering intended product use and the design of available studies supporting product use. The system was optimized with a primary aim to prepare this formulation is to reduce down the concentration of ethanol in formulation by addition of PEG-600 as a co-solvent. All formulations were observed for appearance of color and transparency of gel. The pH of gels was adjusted in the range 6.8 to 7.4. The formulation designed including the ingredients of carbopol 934, PEG (600), ethanol, and water. Evaluation carried out for the formulation with rheological studies. In-vitro diffusion study through flow through diffusion cell method. Drug content uniformity was determined spectrophotometrically. Spreadability indicates that the gel is easily...
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Posted by admin on Jun 30, 2015 in |
Aim And Objective: This review aims to find the sialic acid level in oral cancer patients. Background: Oral cavity cancer is currently the most frequent cause of cancer-related death among Indian men. It is preceded by oral precancerous conditions like leukoplakia or oral sub mucous fibrosis. Altered cell surface topography is the soul of the malignant cell. Early detection is the key to treat oral cancer. Attempts are on to develop sensitive, specific, and reliable biochemical tests for early detection and diagnosis. Glycoproteins and Glycolipids are important constituents of the cell membrane; hence, they play an important role in malignancy. Glycoconjugates are released into the circulation in increased level from malignant cells due to increased turnover, secretion, or shedding of malignant cells. So the measurement of and salivary glycoprotein and glycolipids has received a wide range of acceptance in the screening of oral cancer. Sialic acid is N-acetyl neuraminic acid. It is a negatively charged nine-carbon monosaccharide commonly attached to carbohydrate chains of glycoproteins and glycolipids. Salivary glycoproteins play...
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Posted by admin on Jun 13, 2015 in |
Number of thermal power plants in Singrauli MP (India) has changes air composition, water quality and environmental conditions that consequently affected biodiversity, wildlife and migration of livings in the region. Operational thermal power plants produce enormous quantity of pollutants mostly fly ash as a by product of combustion of coal or any pulverized fuel at higher temperature. Industrial effluents contain several heavy metals distrusted the metabolic process of living organism due to easily dispersion and mobilization in environment. The eatables and applicable potential plants and vegetables altered by these heavy metals and concern derivatives which directly and indirectly posing severe risks to human health which, extremely toxic even in low concentration, and will accumulated in organisms and ecosystems. The National Action Plan on Climate Change must tackle properly the subject of power generation, renewable energy and energy competence sources. Increasing public attentiveness is one of the most important ways to conserve biodiversity. This can be accomplished through educational programs, incentive programs, and volunteer monitoring programs. Various organizations NGO’s and...
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Posted by admin on Jun 13, 2015 in |
A reverse phase isocratic HPLC was developed and validated for the determination of levamisole in pure and tablet dosage forms. Method development was carried out on YMC C18 isocratic column, (250 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature), Shimadzu LC–sol 2010 Prominence Liquid Chromatography. The mobile phase was a mixture of Acetonitrile: methanol 50:50 v/v and the flow rate was set at 1.3 ml/min and UV detection at 236 nm. Validation parameters were evaluated for the method according to the ICH guidelines. In the linearity study, linearity was observed from 2-10 μg/ml with a correlation coefficient of 0.9999 and regression coefficient of 0.999. The limit of detection and limit of quantitation for the method were 0.0209μg/ml and 0.069μg/ml, respectively. The statistical analysis shows that the method was found to be accurate, reliable, simple, and reproducible. The intra and interassay precisions were satisfactory; the values of relative standard deviations did not exceed 2%. The accuracy of the method was proved; the recovery of levamisole...
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