Posted by admin on Apr 29, 2015 in |
Herbal drugs constitute a major part in all the traditional systems of medicine. From the literature review, it comes to know that Acacia arabica stem is used as a chewing stick and claimed to be useful for bleeding gums and pain related to it. In some communities use of leaves is also known. The components are taken from live parts as they are, without allowing them to dry for a long period, which may lead to enzymatic degradation over the process of drying. The juice is dried at room temperature to avoid degradation of heat sensitive moiety if any, that may be present in the juice. This dried juice is expected to have properties which will be useful for the treatment of inflammation. The properties analyzed here are the anti-inflammatory activity of stem and leaf juice. The objective of the proposed study is to perform the phytochemical studies on the fresh juice of babul stem and leaves. It is further envisaged to study anti-inflammatory properties of the dried fresh...
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Posted by admin on Apr 29, 2015 in |
The technological development is leading the human life to be comfortable. It is also gaining important attention as per health concern as it has enhanced the survival of the patients. The development in technology has become a boon to human beings. Electronic Pill is one such technology that is used to strive in opposition to deadly diseases by detecting diseases and abnormalities in the human body. These electronic pills are swallow-able or implantable in the human body to detect biological signals or capture images that are to be used for diagnostic and therapeutic purposes. The sensor-based electronic pills (capsules) are used in modern days to carryout complex treatments and hence, are called to be Pharmacy-on-chip (POC). The concept involves having simple electronic devices that include sensors, drug delivery systems, or tissue simulating tools powered by the batteries. The technology has a range of applications in the detection of disease and abnormalities in medical research. The overall aim has been to deliver enhanced functionality, reduced size, and power consumption, through...
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Posted by admin on Apr 14, 2015 in |
Mucilages of plant origin have been used widely as demulcent because of their unique properties to bind with the mucous membrane. Isolation of water-soluble components from the natural edible sources was carried out by cold/hot aqueous extraction process followed by the organic solvent precipitation. The yield of Pithecellobium dulce (PD), Prosopis juliflora (PJ), Acacia arabica (AA) and Abelmoschus esculanthus (AE) was ≈5.49, 4.91, 3.46, 3.87 % w/w respectively to the initial weight. The isolated mucoadhesive materials obtained from natural sources were proved to be safe and free from toxic or adverse effects. Swollen volumes after 24 h of hydration were found to be 12.1, 12.4, 13.3, and 18.3 indicating their moderate swellability compared to 27.4 of carbopol 934 P (CP), 25.7 of sodium alginate (SAA), 1.2 of guar gum (GG) and 6.4 of hydroxy propyl methyl cellulose (HPMC). The moisture sorption capacities of PD & PJ are very less. The loss on drying of PD, PJ, and AA & AE was less than the official limit of 6%. The...
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Posted by admin on Apr 14, 2015 in |
Diabetes mellitus is one of the most critical health conditions around the world, not only in terms of the number of affected people, disability, and premature mortality but also in regards to the health care costs involved in controlling and treating its complications. Among the most constant ailments, the diabetic patient suffers is the diabetic foot, defined as any infection, ulceration, and necrosis of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular disease of the lower limbs. This study determines the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers. A record based study was conducted among 169 diabetic foot ulcer patients admitted in the hospital; Details regarding the Culture and antibiotic susceptibility of specimens (pus samples from foot ulcers) from these 104 patients were collected. Commonest microorganisms isolated in this study were Pseudomonas, Staphylococcus, Klebsiella, Proteus, and E. coli. Gram-positive organisms were highly sensitive to Vancomycin, Linezolide, and gram-negative were sensitive to Amikacin and...
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Posted by admin on Apr 14, 2015 in |
Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. The present research work was an attempt to formulate and evaluate paliperidone delayed-release tablets. A combination of hydroxypropyl methylcellulose (HPMC K100M) and polyvinyl acetate phthalate, cellulose acetate phthalate were used as polymers. The tablets were prepared by direct compression method. 12 formulations were prepared by changing the ratios of the drug and polymer to study the effect of variable concentrations of polymers and characteristics of the tablets. The prepared tablets were evaluated by different parameters such as Thickness, weight variation, hardness, content uniformity. The tablets were also evaluated for in vitro drug release in 0.1N HCl for 12 h in USP Type II dissolution apparatus. Among all the formulations (F-I to F-XII) prepared, batch F-12 gave good results of Paliperidone when compared to other formulations. Hence, formulation F12 was found to be equivalent to a marketed product with good bioavailability properties. It also showed no significant change in physical appearance and drug...
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