Posted by admin on Jul 12, 2017 in |
Nanoparticles represent a promising drug delivery system of controlled and targeted release. The current research work was to explore a novelistic route for targeting to the brain through the ear by formulating nanosuspension using Escitalopram as a model drug permitting better control over depression. Depression is the second most prevailing disease after cardiovascular diseases. The delivery has overcome the dose dumping problem in case of the oral system. In this research work, significant effort was made to explore the novelistic platform for the ear to the brain. Bio-nano suspensions were prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared of different ratios i.e. 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, 1:10,. The formulations were subjected to various evaluations, including pH, % transmittance, Content uniformity, ex-vivo, stability, release for over 36 h. Different formulations of Escitalopram out of which F1 (1:0.5) was found to be the best formulation having an r2 value of 0.9905 t 80: 22 h and best-fit model was...
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Posted by admin on Jul 12, 2017 in |
A stability-indicating High-Performance Thin-Layer Chromatographic method (HPTLC) was developed and validated as per the International Conference on Harmonization (ICH) guidelines for determination of carvedilol (CRL) both in bulk drug and solid lipid nanoparticles (SLNs). The solvent system comprised of toluene–chloroform-methanol-acetic acid (2.0:2.0:1.0:0.04, v/v/v), gave compact spot of CRL at Rf 0.56 ± 0.05. The spectrodensitometric analysis was performed at 242 nm. The linear graph upon regression analysis showed r2 = 0.998 concerning peak area at the concentration range of 50–1000 ng spot−1. The limit of detection and quantification was found to be 7.9 and 24.2 ng spot-1, respectively. The drug was subjected to stress conditions like acid and alkali hydrolysis, oxidation, photodegradation, dry as well as wet heat treatment and evaluated for stability and degradation product. The acidic and alkaline degradation kinetics was also studied using developed HPTLC method. SLNs were developed using hot melt technique and subjected stability testing along with the commercial...
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Posted by admin on Jul 12, 2017 in |
For each infection or confusion condition of the patient, a legitimate solution is of prime significance to keep up the patient healthy. To accomplish this, the solution or medication is regulated Conventionally by at least one of a few very much characterized and prominent courses of medication organization Including oral, parenteral, rectal, alveolar, and Ocular and topical. Among these previously mentioned mainstream courses, ordinary oral course of medication organization lies at the highest point of the progression of the customary routes. Now a day’s a large portion of the pharmaceutical researchers are included in building up a perfect DDS. Researchers have prevailed to build up a framework that can be as close to a perfect framework, and it urges the researchers to create a controlled discharge framework. For this, due to the trouble in new medications, more accentuation has been given in growing new medication conveyance frameworks for existing medications and also new compound substances. In present venture in light of controlled and support discharge tranquilize conveyance framework, to...
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Posted by admin on Jul 12, 2017 in |
In the Ayurvedic system of medicine, Centella asiatica (gotu kola) is one of the important rejuvenating herbs for nerve and brain cells and is believed to be capable of increasing intelligence, longevity, and memory. It contains several active constituents, and the most important bioactive compounds are triterpenoid saponins, including asiaticoside, centelloside, madecassoside, and asiatic acid. It possesses anti-leprotic, anti-viral, anti-bacterial, anti-tumor activities. Due to its medicinal importance, this plant is being overexploited and to conserve this plant, it is necessary to micropropagate this plant in a laboratory with high biomass...
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Posted by admin on Jul 12, 2017 in |
Background: In the emergency department, doctors face urgent and severe cases that need to be treated quickly with high quality. Therefore, clinicians often face challenges in selecting, initiating and individualizing appropriate drug therapy for patients admitted in the emergency medicine ward. Objective: To assess the prescribing patterns of drugs and to determine the rationality of prescriptions by using World Health Organization prescribing indicators. Materials and Methods: A prospective cross sectional study was carried out in emergency department for six months. About 520 case sheets were reviewed. Data were collected using structural data entry form and analyzed. Descriptive statistics were used to describe the data. Results: The data was collected prospectively and analyzed using WHO prescribing indicators. The average number of drugs prescribed was 6.40 per prescription. The drugs prescribed by generic name accounts for 20.9% and those prescribed from EDL include 83.88%. At least one antibiotic was prescribed for patients which is high (57.31%). Most of drugs were administered through injection for about 49.24%.Patients were mainly admitted for nausea...
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