Posted by admin on Jun 30, 2018 in |
Most of the existing anticancer drugs are very potent small molecules; their efficacy is constrained by their systemic toxicity, narrow therapeutic window, low drug loading, size control, scale up, cost of formulation but also as a result of drug resistance and limited cellular entry. Due to these obstacles, controlled and targeting or localized release technology has been replacing the systemic administration and has shown lots of potential for cancer treatment. Liposomes can be used to provide a sustained release of drugs, which require a prolonged plasma concentration at therapeutic levels to achieve the optimum therapeutic efficacy. In the present work, we formulate liposome containing the anticancer drug ‘6 Mercaptopurine’ for sustained delivery. The drug incorporation was carried out using the ether injection method. The cumulative drug release for the formulations, prepared by ether injection method, F1, F2, F3, F4, F5, and F6 were found to be 66.33%, 63.5%, 68.78%, 62.62%, 63.8%, and 61.25% respectively. The drug release kinetics studies suggest that in the formulations prepared by ether injection method,...
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Posted by admin on May 31, 2018 in |
The purpose of the current review is to enlighten the present and the future perspective on oral fast dissolving films (OFDFs) as a drug delivery system as they are gaining interest as a substitute of fast dissolving tablets. Tablets/capsules to modified release tablets/capsules to oral disintegrating tablet to wafer to the recent development of fast dissolving oral films. Fast dissolving drug delivery systems were first invented in the late 1970s to overcome swallowing difficulties associated with tablets and capsules for pediatric and geriatric patients. Also, solid oral delivery systems do not require sterile conditions and are therefore less expensive to manufacture, but oral drug delivery systems still need some advancements to be made because of their drawbacks related to particular class of patients which includes geriatric, pediatric and dysphagia patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking because of tablet appearance, and patients experienced...
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Posted by admin on May 31, 2018 in |
A Reverse Phase-High Performance Liquid Chromatography method has been developed and validated for the estimation of sodium benzoate and potassium sorbate in food products. The RP-HPLC method for sodium benzoate and potassium sorbate was developed using Luna C18 column (150 mm × 4.6 mm, 5 µm) as stationary phase and acetonitrile: sodium acetate buffer pH 4.3 (20:80) as mobile phase at 1.0 ml/min flow rate and detection was carried out at 235 nm and the methods were validated in accordance with ICH guidelines. Sodium benzoate and potassium sorbate have linearity in the concentration range of 1-30 µg/ml in with correlation coefficient (r2= 0.999 & r2=0.999) respectively. Sodium benzoate and potassium sorbate eluted at 4.9 and 6.9 min, respectively. The values of LOD were 0.59 and 0.39, and LOQ were 1.8 and 1.1 for sodium benzoate and potassium sorbate respectively. Results of assay and validation study are satisfactory. So, the methods can be successfully applied for the routine analysis of sodium benzoate and potassium...
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Posted by admin on Apr 30, 2018 in |
Transdermal drug delivery system was introduced to overcome the difficulties of drug delivery through the oral route. Despite their relatively higher costs, transdermal delivery systems have proved advantageous for delivery of selected drugs, such as estrogens, testosterone, clonidine, and nitro-glycerine. Transdermal delivery provides a leading edge over injectable and oral routes by increasing patient compliance and avoiding the first-pass metabolism, respectively. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Skin is an effective medium from which absorption of the drug takes place and enters into systematic circulation over some time. The present article reviews the selection of drug and polymers suitable to be formulated as a transdermal system, advantages, disadvantages of formulation design, and the methods of preparation and evaluation of...
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Posted by admin on Apr 30, 2018 in |
Amlodipine besylate is a major calcium channel blocker for the treatment of hypertension. Solid dispersion Amlodipine besylate (SD-AB) was prepared by using EC, HPMC, and croscarmellose in different ratios. The development of rapidly disintegrating oral tablets of Amlodipine besylate by direct compression method. The tablets were prepared by using direct compression method and evaluated for weight variations, hardness, friability, wetting time, disintegration time, and dissolution study. Although oral disintegrating tablets are much useful in the cases of the geriatric, pediatric, and traveling patient because of no water required for the administration, therefore, the solid dispersions prepared by a solvent evaporation method using EC, HPMC and croscarmellose carrier can be successfully used for the improvement of dissolution of SD-AB and resulted in a faster onset of action as indicated by in-vivo...
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