Posted by admin on Dec 31, 2018 in |
The buccal cavity is considering as a door for the digestive system. It is composed of teeth, tongue, and palate. When the food enters the buccal cavity, it is moved along the pharynx and esophagus and then go onward through the stomach, small intestine, large intestine, and anal opening. When the drug is taken by the buccal delivery system, it decreases the time needed for the drug to give its action, progresses the therapeutic action of the drug and gives a better enzymatic flora for drug absorption. It provides direct entry of drug into the systemic circulation; therefore, decrease all the drawbacks of the per-oral administration of drugs as hepatic first-pass effect, presystemic elimination of GIT by enzymatic degradation; between different routes of drug delivery, wafers are considered the most advantageous dosage form that taken orally and gives response at once with little side effects. The buccal region is one of the most convenient and easily approachable routes for administration of the therapeutic agents to be used locally and...
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Posted by admin on Dec 31, 2018 in |
Purpose: The main objective of the present research investigation is to formulate the sustained release formulation of Rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belong BCS class-II agent. Methods: The SR tablets of Rosuvastatin were prepared to employ different concentrations of HPMCK4M and SCMC in different combinations by direct compression using 32 factorial designs. The concentration of polymers, HPMCK4M, and SCMC required to achieve the desired drug release was selected as independent variables, X1, and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Results and Discussion: nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results, it was concluded that all the formulation were found to be within the Pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted into different kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for dependent variables. The validity of...
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Posted by admin on Oct 31, 2018 in |
Over the last decade, the public has become increasingly aware of the potentially dangerous, systemic side effects of pain medication. Even readily available over-the-counter drugs like acetaminophen, ibuprofen, and aspirin can cause serious damage to the digestive system as a result of long term usage and/or high dosage. A possible alternative to pills for pain relief is transdermal drug delivery, the transfer of drugs across the skin. Transdermal delivery has the advantage of keeping the drug in the area where it is applied, allowing for a reduced total dose compared to a pill, but there are challenges with the method. The skin evolved as a highly efficient barrier to keep foreign substances out. After a drug gets through the skin, there is the problem of assuring drug is delivered evenly in an effective dose. Current transdermal drug delivery methods such as aspirin creams use chemical enhancers to allow the drugs to pass through the skin. The amount of aspirin that is absorbed by the body is still limited, however,...
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Posted by admin on Oct 30, 2018 in |
Dietary polyphenols, mainly phenolic acids and flavonoids, are the primary sources of antioxidants that can be generally recommended for human consumption. Polyphenols are derived from plant-based food, including fruits, vegetables, spices, herbs, etc. In the present era, there has been a great interest in the health benefits of dietary polyphenols against oxidative stress-related diseases such as diabetes mellitus, cancer, chronic kidney disease, etc. Here, the content presents an overview of dietary polyphenols in the context of relevance to human...
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Posted by admin on Oct 30, 2018 in |
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use, and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half-life of ~5 h, low bioavailability, and extensive first-pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as a transdermal drug delivery system. To formulate and evaluate the transdermal drug delivery system of Glimepiride using polymers such as tristearin, soya lecithin, and Eudragit RS100 by solvent casting technique. Formulation of transdermal patches of glimepiride and optimization of SLN transdermal patches. Central composite design (CCD) was applied by using design-expert to optimize the composition of tristearin and soya lecithin for transdermal drug delivery. Prepared drug loaded SLNs were evaluated for particle size analysis, DSC, Drug entrapment efficiency, SEM, and in-vitro release studies. The present study of formulation and preparation of transdermal patches of Glimipride to provide better efficiency of drug another dosage...
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