Posted by admin on Apr 14, 2015 in |
Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. The present research work was an attempt to formulate and evaluate paliperidone delayed-release tablets. A combination of hydroxypropyl methylcellulose (HPMC K100M) and polyvinyl acetate phthalate, cellulose acetate phthalate were used as polymers. The tablets were prepared by direct compression method. 12 formulations were prepared by changing the ratios of the drug and polymer to study the effect of variable concentrations of polymers and characteristics of the tablets. The prepared tablets were evaluated by different parameters such as Thickness, weight variation, hardness, content uniformity. The tablets were also evaluated for in vitro drug release in 0.1N HCl for 12 h in USP Type II dissolution apparatus. Among all the formulations (F-I to F-XII) prepared, batch F-12 gave good results of Paliperidone when compared to other formulations. Hence, formulation F12 was found to be equivalent to a marketed product with good bioavailability properties. It also showed no significant change in physical appearance and drug...
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Posted by admin on Apr 14, 2015 in |
Sumatriptan is a potent and selective 5-hydroxytryptamine agonist. It is an effective agent in the treatment of acute migraine attack. Sumatriptan is rapidly but incompletely absorbed following oral administration and undergoes first-pass metabolism resulting in a low absolute bioavailability of 15%. The biological half-life of Sumatriptan is about 2.5 h. The aim was to develop gastro-retentive floating microbeads which improve the absolute bioavailability of Sumatriptan by avoiding the presystemic metabolism and thereby to reduce the dose frequency. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to FTIR spectrophotometry, capability of floating in the gastric condition was evaluated. The beads were prepared by Ionotropic gelation method. By using Sodium alginate, hydroxyl propyl methylcellulose K4M and guar gum grade in 1:1, 1:2, 1:3 ratios. The beads were evaluated for percent drug entrapment efficiency, and in-vitro drug release. The in-vitro drug release study of the beads was carried out in simulated gastric media by USP dissolution method. Beads formulated employing Sodium alginate alone could not sustain...
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Posted by admin on Feb 2, 2015 in |
Background: Forced degradation studies are used to determine the degradation pathways and degradation products of the active pharmaceutical ingredients that could form during storage and facilitate formulation development, manufacturing and packaging. Aim: To develop and validate simple and precise stability indicating UV Spectrophotometric method for Metformin Hydrochloride in the bulk and tablet dosage form. Material and Method: Separation of the drug from its degradation products was achieved by UV Spectrophotometric method using distilled water and scanned between 200 to 400 nm. Metformin Hydrochloride was subjected to stress conditions such as hydrolysis (acid and base), oxidation, photolysis, and thermal degradation. The degraded samples were further analyzed by using this method. Results: The maximum absorbance was found to be at 232.2nm and found to be linear over the range 2-10µg/ml with good correlation coefficient (r2) 0.998. The limits of detection and quantification were 0.5232 and 1.5856µg/ml, respectively. Major degradation was observed in acid hydrolysis, photolysis, and oxidative conditions. Metformin Hydrochloride was quite stable under the other stress conditions investigated. Conclusion: The...
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Posted by admin on Feb 2, 2015 in |
In-vitro cytotoxicity testing has become an integral aspect of drug discovery because it is a convenient, cost-effective, and predictive means of characterizing the toxic potential of new chemical entities. The early and routine implementation of this testing is a testament to its prognostic importance for humans. Anticancer activity of different concentrations (20-100) of plant extracts Terminalia arjuna was shown against Hep3-B. MTT [(3, 5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide)] assay was done in-vitro cytotoxicity test. The low concentration does not show the activities were as extract with 80 μl, and 100 μl concentration showed the activity against Human hepatoma cell...
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Posted by admin on Feb 2, 2015 in |
The condensation of 2-imino-5 substituted benzylidene-4-thiazolidinone (1) with thiourea (2) in the presence of glacial acetic acid to gives 2-substituted imino-7-substituted phenyl-3,7-dihydro-2H-[1,3] thiazolo [5,4-e]- thiazin-5-amine (3). The antifungal activities of the compounds (3a-h) were tested against A.niger and A. flavus. The growth of both fungi A. niger and A. flavus are inhibited to some extent by all the synthesized compounds. Hence all are antifungal...
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